Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-23 | Iowa State (21) | 24 | Kansas State (31) | 21 | Final | W | 3 |
| 2 | 2025-08-30 | South Dakota (105) | 7 | Iowa State (21) | 55 | Final | W | 48 |
| 3 | 2025-09-06 | Iowa (33) | 13 | Iowa State (21) | 16 | Final | W | 3 |
| 4 | 2025-09-13 | Iowa State (21) | 24 | Arkansas State (89) | 16 | Final | W | 8 |
| 5 | 2025-09-27 | Arizona (41) | 14 | Iowa State (12) | 39 | Final | W | 25 |
| 6 | 2025-10-04 | Iowa State (27) | 30 | Cincinnati (19) | 38 | Final | L | -8 |
| 7 | 2025-10-11 | Iowa State (36) | 17 | Colorado (54) | 24 | Final | L | -7 |
| 8 | 2025-10-25 | BYU (4) | 41 | Iowa State (38) | 27 | Final | L | -14 |
| 9 | 2025-11-01 | Arizona State (34) | 24 | Iowa State (46) | 19 | Final | L | -5 |
| 10 | 2025-11-08 | Iowa State (40) | 20 | TCU (44) | 17 | Final | W | 3 |
| 11 | 2025-11-21 | Kansas (50) | 0 | Iowa State (21) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | Iowa State (21) | 0 | Oklahoma State (110) | 0 | Scheduled – TBD | – | – |