Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Albany (211) | 7 | Iowa (33) | 34 | Final | W | 27 |
| 2 | 2025-09-06 | Iowa (33) | 13 | Iowa State (21) | 16 | Final | L | -3 |
| 3 | 2025-09-13 | Massachusetts (141) | 0 | Iowa (33) | 0 | Scheduled – 6:30 PM | – | – |
| 4 | 2025-09-19 | Iowa (33) | 0 | Rutgers (52) | 0 | Scheduled – 8:00 PM | – | – |
| 5 | 2025-09-26 | Indiana (6) | 0 | Iowa (33) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-10 | Iowa (33) | 0 | Wisconsin (64) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-17 | Penn State (5) | 0 | Iowa (33) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-24 | Minnesota (32) | 0 | Iowa (33) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-07 | Oregon (2) | 0 | Iowa (33) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-14 | Iowa (33) | 0 | USC (30) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-21 | Michigan State (72) | 0 | Iowa (33) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | Iowa (33) | 0 | Nebraska (47) | 0 | Scheduled – 11:00 AM | – | – |