Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-29 | Western Illinois (223) | 3 | Illinois (17) | 52 | Final | W | 49 |
| 2 | 2025-09-06 | Illinois (17) | 45 | Duke (44) | 19 | Final | W | 26 |
| 3 | 2025-09-13 | Western Michigan (104) | 0 | Illinois (17) | 38 | Final | W | 38 |
| 4 | 2025-09-20 | Illinois (35) | 10 | Indiana (1) | 63 | Final | L | -53 |
| 5 | 2025-09-27 | USC (18) | 32 | Illinois (13) | 34 | Final | W | 2 |
| 6 | 2025-10-04 | Illinois (14) | 43 | Purdue (83) | 27 | Final | W | 16 |
| 7 | 2025-10-11 | Ohio State (2) | 34 | Illinois (13) | 16 | Final | L | -18 |
| 8 | 2025-10-25 | Illinois (32) | 25 | Washington (19) | 42 | Final | L | -17 |
| 9 | 2025-11-01 | Rutgers (66) | 13 | Illinois (23) | 35 | Final | W | 22 |
| 10 | 2025-11-15 | Maryland (78) | Illinois (22) | Scheduled – 2:30 PM | – | – | ||
| 11 | 2025-11-21 | Illinois (17) | 0 | Wisconsin (64) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | Northwestern (90) | 0 | Illinois (17) | 0 | Scheduled – TBD | – | – |