Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | East Carolina (78) | 17 | North Carolina State (83) | 24 | Final | L | -7 |
| 2 | 2025-09-06 | Campbell (229) | 3 | East Carolina (78) | 56 | Final | W | 53 |
| 3 | 2025-09-13 | East Carolina (78) | 0 | Coastal Carolina (99) | 0 | Scheduled – 7:30 PM | – | – |
| 4 | 2025-09-20 | BYU (14) | 0 | East Carolina (78) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-09-25 | Army (24) | 0 | East Carolina (78) | 0 | Scheduled – 7:30 PM | – | – |
| 6 | 2025-10-08 | East Carolina (78) | 0 | Tulane (36) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-16 | Tulsa (143) | 0 | East Carolina (78) | 0 | Scheduled – 7:30 PM | – | – |
| 8 | 2025-11-01 | East Carolina (78) | 0 | Temple (126) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-08 | Charlotte (103) | 0 | East Carolina (78) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-15 | Memphis (34) | 0 | East Carolina (78) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-21 | East Carolina (78) | 0 | UTSA (88) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | East Carolina (78) | 0 | Florida Atlantic (128) | 0 | Scheduled – TBD | – | – |