Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Elon (183) | 17 | Duke (44) | 45 | Final | W | 28 |
| 2 | 2025-09-06 | Illinois (17) | 45 | Duke (44) | 19 | Final | L | -26 |
| 3 | 2025-09-13 | Duke (44) | 0 | Tulane (36) | 0 | Scheduled – 7:00 PM | – | – |
| 4 | 2025-09-20 | North Carolina State (83) | 0 | Duke (44) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-09-27 | Duke (44) | 0 | Syracuse (27) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-03 | Duke (44) | 0 | California (82) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-18 | Georgia Tech (43) | 0 | Duke (44) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-11-01 | Duke (44) | 0 | Clemson (22) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-08 | Duke (44) | 0 | Connecticut (61) | 0 | Scheduled – 3:30 PM | – | – |
| 10 | 2025-11-15 | Virginia (80) | 0 | Duke (44) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-22 | Duke (44) | 0 | North Carolina (79) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Wake Forest (98) | 0 | Duke (44) | 0 | Scheduled – TBD | – | – |