Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | LSU (19) | 17 | Clemson (22) | 10 | Final | L | -7 |
| 2 | 2025-09-06 | Troy (112) | 16 | Clemson (22) | 27 | Final | W | 11 |
| 3 | 2025-09-13 | Clemson (22) | 21 | Georgia Tech (43) | 24 | Final | L | -3 |
| 4 | 2025-09-20 | Syracuse (48) | 34 | Clemson (81) | 21 | Final | L | -13 |
| 5 | 2025-10-04 | Clemson (72) | 38 | North Carolina (117) | 10 | Final | W | 28 |
| 6 | 2025-10-11 | Clemson (57) | 41 | Boston College (130) | 10 | Final | W | 31 |
| 7 | 2025-10-18 | SMU (47) | 35 | Clemson (71) | 24 | Final | L | -11 |
| 8 | 2025-11-01 | Duke (45) | 46 | Clemson (79) | 45 | Final | L | -1 |
| 9 | 2025-11-08 | Florida State (51) | 10 | Clemson (63) | 24 | Final | W | 14 |
| 10 | 2025-11-14 | Clemson (63) | 3 | Louisville (13) | 3 | 13:34 – 2nd Quarter | L | -0 |
| 11 | 2025-11-22 | Furman (241) | 0 | Clemson (22) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Clemson (22) | 0 | South Carolina (13) | 0 | Scheduled – 12:00 PM | – | – |