Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Buffalo (73) | 10 | Minnesota (32) | 23 | Final | L | -13 |
| 2 | 2025-09-06 | St. Francis | 6 | Buffalo (73) | 45 | Final | W | 39 |
| 3 | 2025-09-13 | Buffalo (73) | 31 | Kent State (196) | 28 | Final | W | 3 |
| 4 | 2025-09-20 | Troy (93) | 21 | Buffalo (106) | 17 | Final | L | -4 |
| 5 | 2025-09-27 | Connecticut (82) | 20 | Buffalo (107) | 17 | Final | L | -3 |
| 6 | 2025-10-04 | Eastern Michigan (145) | 30 | Buffalo (97) | 31 | Final/OT | W | 1 |
| 7 | 2025-10-18 | Buffalo (100) | 28 | Massachusetts (178) | 21 | Final | W | 7 |
| 8 | 2025-10-25 | Akron (128) | 24 | Buffalo (115) | 16 | Final | L | -8 |
| 9 | 2025-11-01 | Buffalo (104) | 28 | Bowling Green (118) | 3 | Final | W | 25 |
| 10 | 2025-11-12 | Buffalo (108) | 19 | Central Michigan (106) | 38 | Final | L | -19 |
| 11 | 2025-11-19 | Miami (OH) (59) | 0 | Buffalo (73) | 0 | Scheduled – 7:00 PM | – | – |
| 12 | 2025-11-28 | Ohio (42) | 0 | Buffalo (73) | 0 | Scheduled – 12:00 PM | – | – |