Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-29 | Alabama A&M (286) | 78 | 76 | Samford (203) | Final | L | -2 |
| 2 | 2020-12-01 | Covenant | 73 | 98 | Samford (203) | Final | W | 25 |
| 3 | 2020-12-05 | Samford (203) | 96 | 83 | Belmont (68) | Final | W | 13 |
| 4 | 2020-12-09 | Alabama State (331) | 0 | 0 | Samford (203) | Cancelled | - | - |
| 5 | 2020-12-09 | Alabama State (156) | Samford (138) | Cancelled | - | - | ||
| 6 | 2020-12-12 | Samford (203) | 75 | 79 | Georgia (35) | Final | L | -4 |
| 7 | 2020-12-16 | Samford (203) | 71 | 79 | Troy (127) | Final | L | -8 |
| 8 | 2020-12-19 | Samford (203) | 65 | 63 | Kennesaw State (142) | Final | W | 2 |
| 9 | 2020-12-21 | Belhaven | 84 | 133 | Samford (203) | Final | W | 49 |
| 10 | 2020-12-30 | Virginia Military (357) | 71 | 84 | Samford (203) | Final | W | 13 |
| 11 | 2021-01-02 | Samford (203) | 84 | 94 | Wofford (221) | Final | L | -10 |
| 12 | 2021-01-06 | Samford (203) | 68 | 73 | Chattanooga (291) | Final | L | -5 |
| 13 | 2021-01-09 | Western Carolina (223) | 0 | 0 | Samford (203) | Postponed | - | - |
| 14 | 2021-01-13 | Samford (172) | 0 | 0 | East Tennessee State (152) | Cancelled | - | - |
| 15 | 2021-01-14 | UNC-Greensboro (265) | 87 | 63 | Samford (203) | Final | L | -24 |
| 16 | 2021-01-16 | UNC-Greensboro (265) | 82 | 70 | Samford (203) | Final | L | -12 |
| 17 | 2021-01-18 | Western Carolina (223) | 78 | 82 | Samford (203) | Final | W | 4 |
| 18 | 2021-01-20 | Chattanooga (291) | 70 | 64 | Samford (203) | Final | L | -6 |
| 19 | 2021-01-23 | The Citadel (332) | 0 | 0 | Samford (203) | Cancelled | - | - |
| 20 | 2021-01-27 | Samford (205) | 0 | 0 | Mercer (122) | Cancelled | - | - |
| 21 | 2021-01-30 | Samford (205) | 0 | 0 | Western Carolina (230) | Cancelled | - | - |
| 22 | 2021-02-01 | Samford (208) | 0 | 0 | East Tennessee State (121) | Cancelled | - | - |
| 23 | 2021-02-03 | Furman (157) | 0 | 0 | Samford (203) | Postponed | - | - |
| 24 | 2021-02-06 | Samford | 0 | 0 | UNC-Greensboro | Cancelled | - | - |
| 25 | 2021-02-08 | Samford (203) | 82 | 89 | Mercer (174) | Final/2OT | L | -7 |
| 26 | 2021-02-10 | Mercer (174) | 77 | 70 | Samford (203) | Final/OT | L | -7 |
| 27 | 2021-02-13 | Samford (203) | 56 | 85 | Virginia Military (357) | Final | L | -29 |
| 28 | 2021-02-17 | Samford (203) | 64 | 78 | Furman (157) | Final | L | -14 |
| 29 | 2021-02-20 | East Tennessee State (140) | 0 | 0 | Samford (203) | Cancelled | - | - |
| 30 | 2021-02-22 | Wofford (221) | 0 | 0 | Samford (203) | Cancelled | - | - |
| 31 | 2021-02-27 | Samford (203) | 0 | 0 | The Citadel (332) | Cancelled | - | - |
| 32 | 2021-03-05 | Samford (203) | 59 | 87 | Mercer (174) | Final | L | -28 |