Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Brevard | 42 | 90 | South Carolina Upstate (253) | Final | W | 48 |
| 2 | 2022-11-11 | South Carolina Upstate (253) | 38 | 84 | Duke (25) | Final | L | -46 |
| 3 | 2022-11-15 | South Carolina Upstate (253) | 70 | 81 | Clemson (63) | Final | L | -11 |
| 4 | 2022-11-18 | Coastal Carolina (259) | 78 | 79 | South Carolina Upstate (253) | Final | W | 1 |
| 5 | 2022-11-21 | South Carolina Upstate (253) | 56 | 83 | Air Force (149) | Final | L | -27 |
| 6 | 2022-11-25 | South Carolina Upstate (253) | 53 | 68 | South Carolina (197) | Final | L | -15 |
| 7 | 2022-11-30 | Columbia International | 59 | 93 | South Carolina Upstate (293) | Final | W | 34 |
| 8 | 2022-12-03 | South Carolina Upstate (293) | 79 | 64 | Western Carolina (223) | Final | W | 15 |
| 9 | 2022-12-10 | South Carolina State (350) | 84 | 89 | South Carolina Upstate (253) | Final | W | 5 |
| 10 | 2022-12-13 | South Carolina Upstate (293) | 63 | 80 | Florida State (64) | Final | L | -17 |
| 11 | 2022-12-20 | South Carolina Upstate (253) | 56 | 65 | Kennesaw State (115) | Final | L | -9 |
| 12 | 2022-12-29 | Winthrop (133) | 62 | 70 | South Carolina Upstate (293) | Final | W | 8 |
| 13 | 2022-12-31 | South Carolina Upstate (253) | 85 | 90 | Charleston Southern (324) | Final | L | -5 |
| 14 | 2023-01-04 | South Carolina Upstate (253) | 65 | 60 | Radford (188) | Final | W | 5 |
| 15 | 2023-01-07 | High Point (276) | 57 | 76 | South Carolina Upstate (253) | Final | W | 19 |
| 16 | 2023-01-11 | Campbell (255) | 78 | 63 | South Carolina Upstate (253) | Final | L | -15 |
| 17 | 2023-01-14 | South Carolina Upstate (253) | 65 | 72 | Longwood (180) | Final | L | -7 |
| 18 | 2023-01-18 | Presbyterian (357) | 60 | 61 | South Carolina Upstate (253) | Final | W | 1 |
| 19 | 2023-01-21 | South Carolina Upstate (253) | 58 | 64 | UNC-Asheville (130) | Final | L | -6 |
| 20 | 2023-01-25 | South Carolina Upstate (253) | 66 | 78 | Gardner-Webb (210) | Final | L | -12 |
| 21 | 2023-01-28 | Radford (188) | 55 | 52 | South Carolina Upstate (253) | Final | L | -3 |
| 22 | 2023-02-01 | South Carolina Upstate (253) | 66 | 78 | Campbell (255) | Final | L | -12 |
| 23 | 2023-02-04 | UNC-Asheville (130) | 70 | 76 | South Carolina Upstate (253) | Final | W | 6 |
| 24 | 2023-02-08 | Charleston Southern (324) | 60 | 77 | South Carolina Upstate (253) | Final | W | 17 |
| 25 | 2023-02-11 | South Carolina Upstate (293) | 79 | 70 | Winthrop (133) | Final | W | 9 |
| 26 | 2023-02-15 | Longwood (269) | 67 | 72 | South Carolina Upstate (293) | Final | W | 5 |
| 27 | 2023-02-18 | South Carolina Upstate (293) | 66 | 81 | High Point (69) | Final | L | -15 |
| 28 | 2023-02-22 | South Carolina Upstate (293) | 59 | 57 | Presbyterian (264) | Final | W | 2 |
| 29 | 2023-02-25 | Gardner-Webb (220) | 69 | 75 | South Carolina Upstate (242) | Final | W | 6 |
| 30 | 2023-03-03 | Gardner-Webb (363) | 76 | 77 | South Carolina Upstate (293) | Final | W | 1 |
| 31 | 2023-03-04 | South Carolina Upstate (293) | 62 | 66 | UNC-Asheville (244) | Final | L | -4 |
| 32 | 2023-03-18 | Indiana State (123) | 67 | 62 | South Carolina Upstate (234) | Final | L | -5 |