Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-09 | Bellarmine (231) | 67 | 66 | Louisville (287) | Final | L | -1 |
| 2 | 2022-11-12 | Wright State (211) | 73 | 72 | Louisville (287) | Final | L | -1 |
| 3 | 2022-11-15 | Appalachian State (172) | 61 | 60 | Louisville (287) | Final | L | -1 |
| 4 | 2022-11-21 | Louisville (287) | 54 | 80 | Arkansas (22) | Final | L | -26 |
| 5 | 2022-11-22 | Texas Tech (52) | 70 | 38 | Louisville (287) | Final | L | -32 |
| 6 | 2022-11-23 | Louisville (287) | 62 | 81 | Cincinnati (74) | Final | L | -19 |
| 7 | 2022-11-29 | Maryland (28) | 79 | 54 | Louisville (287) | Final | L | -25 |
| 8 | 2022-12-04 | Miami (16) | 80 | 53 | Louisville (287) | Final | L | -27 |
| 9 | 2022-12-10 | Louisville (287) | 53 | 75 | Florida State (209) | Final | L | -22 |
| 10 | 2022-12-14 | Western Kentucky (154) | 83 | 94 | Louisville (21) | Final | W | 11 |
| 11 | 2022-12-17 | Florida A&M (358) | 55 | 61 | Louisville (287) | Final | W | 6 |
| 12 | 2022-12-20 | Lipscomb (186) | 75 | 67 | Louisville (287) | Final | L | -8 |
| 13 | 2022-12-22 | Louisville (21) | 64 | 76 | North Carolina State (44) | Final | L | -12 |
| 14 | 2022-12-31 | Louisville (287) | 63 | 86 | Kentucky (33) | Final | L | -23 |
| 15 | 2023-01-03 | Syracuse (87) | 70 | 69 | Louisville (287) | Final | L | -1 |
| 16 | 2023-01-07 | Wake Forest (59) | 80 | 72 | Louisville (287) | Final | L | -8 |
| 17 | 2023-01-11 | Louisville (287) | 70 | 83 | Clemson (63) | Final | L | -13 |
| 18 | 2023-01-14 | North Carolina (47) | 80 | 59 | Louisville (287) | Final | L | -21 |
| 19 | 2023-01-18 | Pittsburgh (46) | 75 | 54 | Louisville (287) | Final | L | -21 |
| 20 | 2023-01-25 | Louisville (287) | 65 | 75 | Boston College (142) | Final | L | -10 |
| 21 | 2023-01-28 | Louisville (287) | 62 | 76 | Notre Dame (199) | Final | L | -14 |
| 22 | 2023-02-01 | Georgia Tech (168) | 58 | 68 | Louisville (287) | Final | W | 10 |
| 23 | 2023-02-04 | Florida State (209) | 81 | 78 | Louisville (287) | Final | L | -3 |
| 24 | 2023-02-07 | Louisville (287) | 57 | 91 | Pittsburgh (46) | Final | L | -34 |
| 25 | 2023-02-11 | Louisville (21) | 85 | 93 | Miami (27) | Final | L | -8 |
| 26 | 2023-02-15 | Virginia (14) | 61 | 58 | Louisville (21) | Final | L | -3 |
| 27 | 2023-02-18 | Clemson (36) | 73 | 83 | Louisville (21) | Final | W | 10 |
| 28 | 2023-02-20 | Louisville (287) | 62 | 79 | Duke (25) | Final | L | -17 |
| 29 | 2023-02-25 | Louisville (287) | 67 | 83 | Georgia Tech (167) | Final | L | -16 |
| 30 | 2023-02-28 | Virginia Tech (68) | 71 | 54 | Louisville (291) | Final | L | -17 |
| 31 | 2023-03-04 | Louisville (21) | 60 | 75 | Virginia (14) | Final | L | -15 |
| 32 | 2023-03-07 | Louisville (298) | 62 | 80 | Boston College (127) | Final | L | -18 |