Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | Cal Poly (192) | 64 | 94 | USC (65) | Final | W | 30 |
| 2 | 2025-11-09 | Manhattan (237) | 83 | 114 | USC (65) | Final | W | 31 |
| 3 | 2025-11-14 | Illinois State (118) | 67 | 87 | USC (65) | Final | W | 20 |
| 4 | 2025-11-20 | Troy (108) | 106 | 107 | USC (65) | Final/3OT | W | 1 |
| 5 | 2025-11-24 | USC (65) | 70 | 67 | Boise State (53) | Final | W | 3 |
| 6 | 2025-11-25 | Seton Hall (222) | 81 | 83 | USC (65) | Final | W | 2 |
| 7 | 2025-11-26 | USC (65) | 88 | 75 | Arizona State (82) | Final | W | 13 |
| 8 | 2025-12-02 | USC (7) | 82 | 77 | Oregon (149) | Final | W | 5 |
| 9 | 2025-12-06 | Washington (78) | 84 | 76 | USC (7) | Final | L | -8 |
| 10 | 2025-12-09 | USC (20) | 94 | 81 | San Diego (295) | Final | W | 13 |
| 11 | 2025-12-14 | Washington State (218) | 61 | 68 | USC (16) | Final | W | 7 |
| 12 | 2025-12-17 | UTSA (269) | 70 | 97 | USC (16) | Final | W | 27 |
| 13 | 2025-12-21 | Brown | USC | Scheduled – 1:00 PM | – | – | ||
| 14 | 2025-12-21 | California-Santa Cruz | 63 | 102 | USC (18) | Final | W | 39 |
| 15 | 2026-01-02 | USC (22) | 66 | 96 | Michigan (1) | Final | L | -30 |
| 16 | 2026-01-05 | USC (27) | 51 | 80 | Michigan State (11) | Final | L | -29 |
| 17 | 2026-01-09 | USC (27) | 70 | 69 | Minnesota (94) | Final/OT | W | 1 |
| 18 | 2026-01-13 | Maryland (158) | 71 | 88 | USC (37) | Final | W | 17 |
| 19 | 2026-01-17 | Purdue (7) | 69 | 64 | USC (37) | Final | L | -5 |
| 20 | 2026-01-21 | Northwestern (100) | 74 | 68 | USC (38) | Final | L | -6 |
| 21 | 2026-01-25 | USC (44) | 73 | 71 | Wisconsin (39) | Final | W | 2 |
| 22 | 2026-01-28 | USC (44) | 72 | 73 | Iowa (33) | Final | L | -1 |
| 23 | 2026-01-31 | Rutgers (135) | 75 | 78 | USC (44) | Final | W | 3 |
| 24 | 2026-02-03 | Indiana (36) | 75 | 81 | USC (46) | Final | W | 6 |
| 25 | 2026-02-08 | USC (43) | 77 | 75 | Penn State (135) | Final | W | 2 |
| 26 | 2026-02-11 | USC (43) | 82 | 89 | Ohio State (45) | Final | L | -7 |
| 27 | 2026-02-18 | Illinois (10) | 101 | 65 | USC (48) | Final | L | -36 |
| 28 | 2026-02-21 | Oregon (100) | 71 | 70 | USC (48) | Final | L | -1 |
| 29 | 2026-02-24 | USC (51) | UCLA (40) | Scheduled – 8:00 PM | – | – | ||
| 30 | 2026-02-28 | Nebraska | USC | Scheduled – 1:00 PM | – | – | ||
| 31 | 2026-03-04 | USC | Washington | Scheduled – 7:30 PM | – | – | ||
| 32 | 2026-03-07 | UCLA | USC | Scheduled – 6:00 PM | – | – |