Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | Southeast Missouri State (182) | 67 | 92 | Saint Louis (119) | Final | L | -25 |
| 2 | 2025-11-07 | Southeast Missouri State (182) | 84 | 89 | Missouri (21) | Final | L | -5 |
| 3 | 2025-11-12 | Webster | 41 | 87 | Southeast Missouri State (182) | Final | W | 46 |
| 4 | 2025-11-15 | St. Thomas (143) | 84 | 72 | Southeast Missouri State (182) | Final | L | -12 |
| 5 | 2025-11-18 | Southeast Missouri State (182) | 70 | 99 | Iowa (60) | Final | L | -29 |
| 6 | 2025-11-25 | Southeast Missouri State (182) | 84 | 68 | Cal Poly (192) | Final | W | 16 |
| 7 | 2025-11-26 | Southeast Missouri State (182) | 72 | 79 | Northern Arizona (256) | Final | L | -7 |
| 8 | 2025-11-29 | Lipscomb (106) | 88 | 77 | Southeast Missouri State (182) | Final | L | -11 |
| 9 | 2025-12-02 | Saint Mary-of-the-Woods | 57 | 88 | Southeast Missouri State (240) | Final | W | 31 |
| 10 | 2025-12-06 | Southeast Missouri State (240) | 74 | 70 | Chattanooga (287) | Final | W | 4 |
| 11 | 2025-12-14 | St. Xavier | 65 | 88 | Southeast Missouri State (246) | Final | W | 23 |
| 12 | 2025-12-18 | Southeast Missouri State (246) | 74 | 85 | Tennessee Tech (241) | Final | L | -11 |
| 13 | 2025-12-20 | Southeast Missouri State (246) | 91 | 82 | Tennessee State (227) | Final | W | 9 |
| 14 | 2026-01-01 | Eastern Illinois (309) | 59 | 68 | Southeast Missouri State (251) | Final | W | 9 |
| 15 | 2026-01-03 | Western Illinois (343) | 50 | 73 | Southeast Missouri State (251) | Final | W | 23 |
| 16 | 2026-01-08 | Southeast Missouri State (239) | Southern Indiana (354) | Scheduled – 7:30 PM | – | – | ||
| 17 | 2026-01-10 | Southeast Missouri State | Morehead State | Scheduled – 3:30 PM | – | – | ||
| 18 | 2026-01-15 | Lindenwood | Southeast Missouri State | Scheduled – 8:00 PM | – | – | ||
| 19 | 2026-01-17 | SIU-Edwardsville | Southeast Missouri State | Scheduled – 3:45 PM | – | – | ||
| 20 | 2026-01-20 | Tennessee-Martin | Southeast Missouri State | Scheduled – 7:30 PM | – | – | ||
| 21 | 2026-01-22 | Little Rock | Southeast Missouri State | Scheduled – 7:30 PM | – | – | ||
| 22 | 2026-01-29 | Southeast Missouri State | Western Illinois | Scheduled – 7:30 PM | – | – | ||
| 23 | 2026-01-31 | Southeast Missouri State | Eastern Illinois | Scheduled – 3:30 PM | – | – | ||
| 24 | 2026-02-05 | Morehead State | Southeast Missouri State | Scheduled – 7:30 PM | – | – | ||
| 25 | 2026-02-07 | Southern Indiana | Southeast Missouri State | Scheduled – 3:45 PM | – | – | ||
| 26 | 2026-02-12 | Southeast Missouri State | SIU-Edwardsville | Scheduled – 7:30 PM | – | – | ||
| 27 | 2026-02-14 | Southeast Missouri State | Lindenwood | Scheduled – 3:30 PM | – | – | ||
| 28 | 2026-02-17 | Southeast Missouri State | Tennessee-Martin | Scheduled – 7:30 PM | – | – | ||
| 29 | 2026-02-21 | Southeast Missouri State | Little Rock | Scheduled – 3:00 PM | – | – | ||
| 30 | 2026-02-26 | Tennessee State | Southeast Missouri State | Scheduled – 7:30 PM | – | – | ||
| 31 | 2026-02-28 | Tennessee Tech | Southeast Missouri State | Scheduled – 3:45 PM | – | – |