Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | South Carolina Upstate (347) | 75 | 87 | California Baptist (176) | Final | L | -12 |
| 2 | 2025-11-05 | South Carolina Upstate (347) | 67 | 66 | Fresno State (313) | Final | W | 1 |
| 3 | 2025-11-08 | Southern Virginia | 46 | 105 | South Carolina Upstate (347) | Final | W | 59 |
| 4 | 2025-11-12 | Bob Jones | 53 | 114 | South Carolina Upstate (347) | Final | W | 61 |
| 5 | 2025-11-15 | South Carolina Upstate (347) | 60 | 73 | UNC-Wilmington (95) | Final | L | -13 |
| 6 | 2025-11-19 | Tennessee Tech (290) | 88 | 84 | South Carolina Upstate (347) | Final | L | -4 |
| 7 | 2025-11-21 | South Carolina Upstate (347) | 64 | 72 | West Georgia (349) | Final | L | -8 |
| 8 | 2025-11-25 | North Carolina Central (306) | 67 | 82 | South Carolina Upstate (347) | Final | W | 15 |
| 9 | 2025-11-29 | South Carolina Upstate (347) | 63 | 72 | Nebraska (51) | Final | L | -9 |
| 10 | 2025-12-03 | Coastal Carolina (141) | 78 | 85 | South Carolina Upstate (214) | Final/OT | W | 7 |
| 11 | 2025-12-06 | Western Carolina (206) | 67 | 78 | South Carolina Upstate (214) | Final | W | 11 |
| 12 | 2025-12-13 | South Carolina Upstate (158) | 62 | 80 | North Carolina (13) | Final | L | -18 |
| 13 | 2025-12-16 | South Carolina Upstate (164) | 78 | 72 | South Carolina State (364) | Final | W | 6 |
| 14 | 2025-12-17 | Southern Wesleyan | 63 | 98 | South Carolina Upstate (164) | Final | W | 35 |
| 15 | 2025-12-20 | South Carolina Upstate (164) | 65 | 74 | Youngstown State (151) | Final | L | -9 |
| 16 | 2025-12-31 | Radford (296) | 76 | 69 | South Carolina Upstate (189) | Final | L | -7 |
| 17 | 2026-01-03 | South Carolina Upstate (189) | 77 | 86 | Presbyterian (273) | Final | L | -9 |
| 18 | 2026-01-10 | Winthrop (225) | 71 | 50 | South Carolina Upstate (242) | Final | L | -21 |
| 19 | 2026-01-14 | South Carolina Upstate (261) | 86 | 81 | Charleston Southern (224) | Final/OT | W | 5 |
| 20 | 2026-01-17 | South Carolina Upstate (261) | 69 | 89 | High Point (92) | Final | L | -20 |
| 21 | 2026-01-21 | UNC-Asheville (260) | 83 | 69 | South Carolina Upstate (250) | Final | L | -14 |
| 22 | 2026-01-23 | South Carolina Upstate (250) | 65 | 67 | Gardner-Webb (364) | Final | L | -2 |
| 23 | 2026-01-29 | Longwood (262) | 60 | 65 | South Carolina Upstate (279) | Final | W | 5 |
| 24 | 2026-02-04 | South Carolina Upstate (263) | 67 | 76 | UNC-Asheville (249) | Final | L | -9 |
| 25 | 2026-02-07 | Charleston Southern (256) | 94 | 100 | South Carolina Upstate (263) | Final/OT | W | 6 |
| 26 | 2026-02-12 | High Point (79) | 95 | 70 | South Carolina Upstate (261) | Final | L | -25 |
| 27 | 2026-02-14 | South Carolina Upstate (261) | 75 | 82 | Longwood (275) | Final/OT | L | -7 |
| 28 | 2026-02-19 | South Carolina Upstate (276) | 64 | 68 | Winthrop (115) | Final | L | -4 |
| 29 | 2026-02-21 | Presbyterian (263) | 74 | 76 | South Carolina Upstate (276) | Final | W | 2 |
| 30 | 2026-02-26 | South Carolina Upstate | Radford | Scheduled – 7:00 PM | – | – | ||
| 31 | 2026-02-28 | Gardner-Webb | South Carolina Upstate | Scheduled – 2:00 PM | – | – |