Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | Colgate (266) | 69 | 80 | Michigan State (7) | Final | W | 11 |
| 2 | 2025-11-08 | Arkansas (31) | 66 | 69 | Michigan State (7) | Final | W | 3 |
| 3 | 2025-11-13 | San Jose State (177) | 60 | 79 | Michigan State (7) | Final | W | 19 |
| 4 | 2025-11-18 | Michigan State | Kentucky | Scheduled – 6:30 PM | – | – | ||
| 5 | 2025-11-21 | Detroit | Michigan State | Scheduled – 6:30 PM | – | – | ||
| 6 | 2025-11-25 | Michigan State | East Carolina | Scheduled – 1:00 PM | – | – | ||
| 7 | 2025-11-27 | North Carolina | Michigan State | Scheduled – 4:30 PM | – | – | ||
| 8 | 2025-12-02 | Iowa | Michigan State | Scheduled – 7:00 PM | – | – | ||
| 9 | 2025-12-06 | Duke | Michigan State | Scheduled – 12:00 PM | – | – | ||
| 10 | 2025-12-13 | Michigan State | Penn State | Scheduled – 12:00 PM | – | – | ||
| 11 | 2025-12-16 | Toledo | Michigan State | Scheduled – 6:30 PM | – | – | ||
| 12 | 2025-12-20 | Oakland | Michigan State | Scheduled – 12:00 PM | – | – | ||
| 13 | 2025-12-29 | Cornell | Michigan State | Scheduled – 7:00 PM | – | – | ||
| 14 | 2026-01-02 | Michigan State | Nebraska | Scheduled – 8:00 PM | – | – | ||
| 15 | 2026-01-05 | USC | Michigan State | Scheduled – 8:30 PM | – | – | ||
| 16 | 2026-01-08 | Northwestern | Michigan State | Scheduled – 6:30 PM | – | – | ||
| 17 | 2026-01-13 | Indiana | Michigan State | Scheduled – 8:00 PM | – | – | ||
| 18 | 2026-01-16 | Michigan State | Washington | Scheduled – 9:00 PM | – | – | ||
| 19 | 2026-01-20 | Michigan State | Oregon | Scheduled – 6:00 PM | – | – | ||
| 20 | 2026-01-24 | Maryland | Michigan State | Scheduled – 12:00 PM | – | – | ||
| 21 | 2026-01-27 | Michigan State | Rutgers | Scheduled – 6:30 PM | – | – | ||
| 22 | 2026-01-30 | Michigan | Michigan State | Scheduled – 8:00 PM | – | – | ||
| 23 | 2026-02-04 | Michigan State | Minnesota | Scheduled – 6:00 PM | – | – | ||
| 24 | 2026-02-07 | Illinois | Michigan State | Scheduled – 8:00 PM | – | – | ||
| 25 | 2026-02-13 | Michigan State | Wisconsin | Scheduled – 7:00 PM | – | – | ||
| 26 | 2026-02-17 | UCLA | Michigan State | Scheduled – 8:30 PM | – | – | ||
| 27 | 2026-02-22 | Ohio State | Michigan State | Scheduled – 1:00 PM | – | – | ||
| 28 | 2026-02-26 | Michigan State | Purdue | Scheduled – 8:00 PM | – | – | ||
| 29 | 2026-03-01 | Michigan State | Indiana | Scheduled – 3:45 PM | – | – | ||
| 30 | 2026-03-05 | Rutgers | Michigan State | Scheduled – 8:00 PM | – | – | ||
| 31 | 2026-03-08 | Michigan State | Michigan | Scheduled – 5:30 PM | – | – |