Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | South Carolina State (211) | 45 | 104 | Louisville (18) | Final | W | 59 |
| 2 | 2025-11-06 | Jackson State (268) | 70 | 106 | Louisville (18) | Final | W | 36 |
| 3 | 2025-11-11 | Kentucky (9) | 88 | 96 | Louisville (18) | Final | W | 8 |
| 4 | 2025-11-15 | Ohio | Louisville | Scheduled – 12:00 PM | – | – | ||
| 5 | 2025-11-21 | Louisville | Cincinnati | Scheduled – 6:30 PM | – | – | ||
| 6 | 2025-11-24 | Eastern Michigan | Louisville | Scheduled – 7:00 PM | – | – | ||
| 7 | 2025-11-26 | NJIT | Louisville | Scheduled – 9:00 PM | – | – | ||
| 8 | 2025-12-03 | Louisville | Arkansas | Scheduled – 6:15 PM | – | – | ||
| 9 | 2025-12-06 | Louisville | Indiana | Scheduled – 2:00 PM | – | – | ||
| 10 | 2025-12-13 | Memphis | Louisville | Scheduled – 3:30 PM | – | – | ||
| 11 | 2025-12-16 | Louisville | Tennessee | Scheduled – 7:00 PM | – | – | ||
| 12 | 2025-12-20 | Montana | Louisville | Scheduled – 12:00 PM | – | – | ||
| 13 | 2025-12-30 | Louisville | California | Scheduled – 6:00 PM | – | – | ||
| 14 | 2026-01-02 | Louisville | Stanford | Scheduled – 5:00 PM | – | – | ||
| 15 | 2026-01-06 | Duke | Louisville | Scheduled – 7:00 PM | – | – | ||
| 16 | 2026-01-10 | Boston College | Louisville | Scheduled – 12:00 PM | – | – | ||
| 17 | 2026-01-13 | Virginia | Louisville | Scheduled – 7:00 PM | – | – | ||
| 18 | 2026-01-17 | Louisville | Pittsburgh | Scheduled – 8:00 PM | – | – | ||
| 19 | 2026-01-24 | Virginia Tech | Louisville | Scheduled – 3:30 PM | – | – | ||
| 20 | 2026-01-26 | Louisville | Duke | Scheduled – 7:00 PM | – | – | ||
| 21 | 2026-01-31 | SMU | Louisville | Scheduled – 2:00 PM | – | – | ||
| 22 | 2026-02-04 | Notre Dame | Louisville | Scheduled – 7:00 PM | – | – | ||
| 23 | 2026-02-07 | Louisville | Wake Forest | Scheduled – 12:00 PM | – | – | ||
| 24 | 2026-02-09 | North Carolina State | Louisville | Scheduled – 7:00 PM | – | – | ||
| 25 | 2026-02-14 | Louisville | Baylor | Scheduled – 3:00 PM | – | – | ||
| 26 | 2026-02-17 | Louisville | SMU | Scheduled – 7:00 PM | – | – | ||
| 27 | 2026-02-21 | Georgia Tech | Louisville | Scheduled – 2:15 PM | – | – | ||
| 28 | 2026-02-23 | Louisville | North Carolina | Scheduled – 7:00 PM | – | – | ||
| 29 | 2026-02-28 | Louisville | Clemson | Scheduled – 12:00 AM | – | – | ||
| 30 | 2026-03-03 | Syracuse | Louisville | Scheduled – 9:00 PM | – | – | ||
| 31 | 2026-03-07 | Louisville | Miami | Scheduled – 2:00 PM | – | – |