Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | Lehigh (311) | 57 | 75 | Houston (4) | Final | W | 18 |
| 2 | 2025-11-08 | Towson (131) | 48 | 65 | Houston (4) | Final | W | 17 |
| 3 | 2025-11-12 | Oakland (189) | 45 | 78 | Houston (4) | Final | W | 33 |
| 4 | 2025-11-16 | Houston | Auburn | Scheduled – 2:00 PM | – | – | ||
| 5 | 2025-11-20 | Rider | Houston | Scheduled – 8:00 PM | – | – | ||
| 6 | 2025-11-24 | Syracuse | Houston | Scheduled – 3:00 PM | – | – | ||
| 7 | 2025-11-25 | Tennessee | Houston | Scheduled – 3:00 PM | – | – | ||
| 8 | 2025-12-06 | Florida State | Houston | Scheduled – 7:00 PM | – | – | ||
| 9 | 2025-12-10 | Jackson State | Houston | Scheduled – 7:00 PM | – | – | ||
| 10 | 2025-12-13 | New Orleans | Houston | Scheduled – 2:00 PM | – | – | ||
| 11 | 2025-12-20 | Houston | Arkansas | Scheduled – 5:30 PM | – | – | ||
| 12 | 2025-12-29 | Middle Tennessee | Houston | Scheduled – 7:00 PM | – | – | ||
| 13 | 2026-01-03 | Houston | Cincinnati | Scheduled – 2:00 PM | – | – | ||
| 14 | 2026-01-06 | Texas Tech | Houston | Scheduled – 8:00 PM | – | – | ||
| 15 | 2026-01-10 | Houston | Baylor | Scheduled – 12:00 PM | – | – | ||
| 16 | 2026-01-13 | West Virginia | Houston | Scheduled – 7:30 PM | – | – | ||
| 17 | 2026-01-18 | Arizona State | Houston | Scheduled – 4:00 PM | – | – | ||
| 18 | 2026-01-24 | Houston | Texas Tech | Scheduled – 5:30 PM | – | – | ||
| 19 | 2026-01-28 | Houston | TCU | Scheduled – 8:00 PM | – | – | ||
| 20 | 2026-01-31 | Cincinnati | Houston | Scheduled – 11:00 AM | – | – | ||
| 21 | 2026-02-04 | Central Florida | Houston | Scheduled – 6:00 PM | – | – | ||
| 22 | 2026-02-07 | Houston | BYU | Scheduled – 8:30 PM | – | – | ||
| 23 | 2026-02-10 | Houston | Utah | Scheduled – 7:00 PM | – | – | ||
| 24 | 2026-02-14 | Kansas State | Houston | Scheduled – 8:00 PM | – | – | ||
| 25 | 2026-02-16 | Houston | Iowa State | Scheduled – 8:00 PM | – | – | ||
| 26 | 2026-02-21 | Arizona | Houston | Scheduled – 2:00 PM | – | – | ||
| 27 | 2026-02-23 | Houston | Kansas | Scheduled – 8:00 PM | – | – | ||
| 28 | 2026-02-28 | Colorado | Houston | Scheduled – 11:00 AM | – | – | ||
| 29 | 2026-03-04 | Baylor | Houston | Scheduled – 8:00 PM | – | – | ||
| 30 | 2026-03-07 | Houston | Oklahoma State | Scheduled – 11:00 AM | – | – |