Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Missouri State (134) | 13 | USC (30) | 73 | Final | W | 60 |
| 2 | 2025-09-06 | Georgia Southern (62) | 20 | USC (30) | 59 | Final | W | 39 |
| 3 | 2025-09-13 | USC (30) | 33 | Purdue (133) | 17 | Final | W | 16 |
| 4 | 2025-09-20 | Michigan State (13) | 31 | USC (29) | 45 | Final | W | 14 |
| 5 | 2025-09-27 | USC (18) | 32 | Illinois (13) | 34 | Final | L | -2 |
| 6 | 2025-10-11 | Michigan (29) | 13 | USC (9) | 31 | Final | W | 18 |
| 7 | 2025-10-18 | USC (20) | 24 | Notre Dame (8) | 34 | Final | L | -10 |
| 8 | 2025-11-01 | USC (17) | 21 | Nebraska (32) | 17 | Final | W | 4 |
| 9 | 2025-11-07 | Northwestern (55) | 17 | USC (12) | 38 | Final | W | 21 |
| 10 | 2025-11-15 | Iowa (29) | 21 | USC (12) | 26 | Final | W | 5 |
| 11 | 2025-11-22 | USC (15) | 27 | Oregon (4) | 42 | Final | L | -15 |
| 12 | 2025-11-29 | UCLA (82) | 10 | USC (17) | 29 | Final | W | 19 |