Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Mississippi State (108) | 34 | Southern Miss (157) | 17 | Final | L | -17 |
| 2 | 2025-09-06 | Jackson State (136) | 20 | Southern Miss (157) | 38 | Final | W | 18 |
| 3 | 2025-09-13 | Appalachian State (93) | 22 | Southern Miss (157) | 38 | Final | W | 16 |
| 4 | 2025-09-20 | Southern Miss (73) | 20 | Louisiana Tech (40) | 30 | Final | L | -10 |
| 5 | 2025-09-27 | Jacksonville State (112) | 25 | Southern Miss (72) | 42 | Final | W | 17 |
| 6 | 2025-10-09 | Southern Miss (68) | 38 | Georgia Southern (111) | 35 | Final | W | 3 |
| 7 | 2025-10-18 | Southern Miss (62) | 22 | Louisiana (125) | 10 | Final | W | 12 |
| 8 | 2025-10-25 | Louisiana-Monroe (116) | 21 | Southern Miss (60) | 49 | Final | W | 28 |
| 9 | 2025-11-08 | Southern Miss (53) | 27 | Arkansas State (99) | 21 | Final | W | 6 |
| 10 | 2025-11-15 | Texas State (98) | 41 | Southern Miss (70) | 14 | Final | L | -27 |
| 11 | 2025-11-22 | Southern Miss (81) | 35 | South Alabama (113) | 42 | Final | L | -7 |
| 12 | 2025-11-29 | Troy (79) | 28 | Southern Miss (91) | 18 | Final | L | -10 |