Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | New Mexico (123) | 17 | Michigan (18) | 34 | Final | W | 17 |
| 2 | 2025-09-06 | Michigan (18) | 13 | Oklahoma (41) | 24 | Final | L | -11 |
| 3 | 2025-09-13 | Central Michigan (122) | 3 | Michigan (18) | 63 | Final | W | 60 |
| 4 | 2025-09-20 | Michigan (15) | 30 | Nebraska (36) | 27 | Final | W | 3 |
| 5 | 2025-10-04 | Wisconsin (81) | 10 | Michigan (13) | 24 | Final | W | 14 |
| 6 | 2025-10-11 | Michigan (29) | 13 | USC (9) | 31 | Final | L | -18 |
| 7 | 2025-10-18 | Washington (30) | 7 | Michigan (22) | 24 | Final | W | 17 |
| 8 | 2025-10-25 | Michigan (17) | 31 | Michigan State (91) | 20 | Final | W | 11 |
| 9 | 2025-11-01 | Purdue (109) | 16 | Michigan (19) | 21 | Final | W | 5 |
| 10 | 2025-11-15 | Michigan (15) | 24 | Northwestern (53) | 22 | Final | W | 2 |
| 11 | 2025-11-22 | Michigan (16) | 45 | Maryland (85) | 20 | Final | W | 25 |
| 12 | 2025-11-29 | Ohio State (2) | 27 | Michigan (18) | 9 | Final | L | -18 |