Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | LSU (19) | 17 | Clemson (22) | 10 | Final | W | 7 |
| 2 | 2025-09-06 | Louisiana Tech (125) | 7 | LSU (19) | 23 | Final | W | 16 |
| 3 | 2025-09-13 | Florida (25) | 10 | LSU (19) | 20 | Final | W | 10 |
| 4 | 2025-09-20 | Southeastern Louisiana (168) | 10 | LSU (10) | 56 | Final | W | 46 |
| 5 | 2025-09-27 | LSU (22) | 19 | Ole Miss (2) | 24 | Final | L | -5 |
| 6 | 2025-10-11 | South Carolina (63) | 10 | LSU (14) | 20 | Final | W | 10 |
| 7 | 2025-10-18 | LSU (28) | 24 | Vanderbilt (15) | 31 | Final | L | -7 |
| 8 | 2025-10-25 | Texas A&M (3) | 49 | LSU (34) | 25 | Final | L | -24 |
| 9 | 2025-11-08 | LSU (35) | 9 | Alabama (5) | 20 | Final | L | -11 |
| 10 | 2025-11-15 | Arkansas (92) | 22 | LSU (33) | 23 | Final | W | 1 |
| 11 | 2025-11-22 | Western Kentucky (66) | 10 | LSU (29) | 13 | Final | W | 3 |
| 12 | 2025-11-29 | LSU (31) | 13 | Oklahoma (11) | 17 | Final | L | -4 |