Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Albany (211) | 7 | Iowa (33) | 34 | Final | W | 27 |
| 2 | 2025-09-06 | Iowa (33) | 13 | Iowa State (21) | 16 | Final | L | -3 |
| 3 | 2025-09-13 | Massachusetts (141) | 7 | Iowa (33) | 47 | Final | W | 40 |
| 4 | 2025-09-19 | Iowa (47) | 38 | Rutgers (54) | 28 | Final | W | 10 |
| 5 | 2025-09-27 | Indiana (1) | 20 | Iowa (50) | 15 | Final | L | -5 |
| 6 | 2025-10-11 | Iowa (40) | 37 | Wisconsin (92) | 0 | Final | W | 37 |
| 7 | 2025-10-18 | Penn State (75) | 24 | Iowa (37) | 25 | Final | W | 1 |
| 8 | 2025-10-25 | Minnesota (48) | 3 | Iowa (30) | 41 | Final | W | 38 |
| 9 | 2025-11-08 | Oregon (8) | 18 | Iowa (25) | 16 | Final | L | -2 |
| 10 | 2025-11-15 | Iowa (29) | 21 | USC (12) | 26 | Final | L | -5 |
| 11 | 2025-11-22 | Michigan State (100) | 17 | Iowa (26) | 20 | Final | W | 3 |
| 12 | 2025-11-28 | Iowa (21) | 40 | Nebraska (48) | 16 | Final | W | 24 |