Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-02 | Southeast Missouri State | Saint Louis | Scheduled – 11:00 PM | – | – | ||
| 2 | 2025-11-06 | Southeast Missouri State | Missouri | Scheduled – 11:00 PM | – | – | ||
| 3 | 2025-11-11 | Webster | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 4 | 2025-11-14 | St. Thomas | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 5 | 2025-11-17 | Southeast Missouri State | Iowa | Scheduled – 11:00 PM | – | – | ||
| 6 | 2025-11-25 | Southeast Missouri State | Cal Poly | Scheduled – 12:00 AM | – | – | ||
| 7 | 2025-11-26 | Southeast Missouri State | Northern Arizona | Scheduled – 6:00 PM | – | – | ||
| 8 | 2025-11-29 | Lipscomb | Southeast Missouri State | Scheduled – 12:00 PM | – | – | ||
| 9 | 2025-12-01 | Saint Mary-of-the-Woods | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 10 | 2025-12-06 | Southeast Missouri State | Chattanooga | Scheduled – 3:00 PM | – | – | ||
| 11 | 2025-12-13 | St. Xavier | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 12 | 2025-12-17 | Southeast Missouri State | Tennessee Tech | Scheduled – 11:00 PM | – | – | ||
| 13 | 2025-12-20 | Southeast Missouri State | Tennessee State | Scheduled – 3:30 PM | – | – | ||
| 14 | 2025-12-30 | Westminster College | 39 | 88 | Southeast Missouri State (217) | Final | W | 49 |
| 15 | 2025-12-31 | Eastern Illinois | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 16 | 2026-01-03 | Western Illinois | Southeast Missouri State | Scheduled – 3:30 PM | – | – | ||
| 17 | 2026-01-08 | Southeast Missouri State | Southern Indiana | Scheduled – 7:30 PM | – | – | ||
| 18 | 2026-01-10 | Southeast Missouri State | Morehead State | Scheduled – 12:00 AM | – | – | ||
| 19 | 2026-01-14 | Lindenwood | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 20 | 2026-01-16 | SIU-Edwardsville | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 21 | 2026-01-20 | Tennessee-Martin | Southeast Missouri State | Scheduled – 7:30 PM | – | – | ||
| 22 | 2026-01-21 | Little Rock | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 23 | 2026-01-29 | Southeast Missouri State | Western Illinois | Scheduled – 7:30 PM | – | – | ||
| 24 | 2026-01-30 | Southeast Missouri State | Eastern Illinois | Scheduled – 11:00 PM | – | – | ||
| 25 | 2026-02-04 | Morehead State | Southeast Missouri State | Scheduled – 11:00 PM | – | – | ||
| 26 | 2026-02-07 | Southern Indiana | Southeast Missouri State | Scheduled – 3:45 PM | – | – | ||
| 27 | 2026-02-11 | Southeast Missouri State | SIU-Edwardsville | Scheduled – 11:00 PM | – | – | ||
| 28 | 2026-02-13 | Southeast Missouri State | Lindenwood | Scheduled – 11:00 PM | – | – | ||
| 29 | 2026-02-17 | Southeast Missouri State | Tennessee-Martin | Scheduled – 7:30 PM | – | – | ||
| 30 | 2026-02-20 | Southeast Missouri State | Little Rock | Scheduled – 11:00 PM | – | – | ||
| 31 | 2026-02-26 | Tennessee State | Southeast Missouri State | Scheduled – 7:30 PM | – | – | ||
| 32 | 2026-02-27 | Tennessee Tech | Southeast Missouri State | Scheduled – 11:00 PM | – | – |