NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | St. Louis Pharmacy | 48 | 60 | Southeast Missouri State (332) | Final | W | 12 |
| 2 | 2022-11-10 | Southeast Missouri State (332) | 57 | 83 | Ole Miss (19) | Final | L | -26 |
| 3 | 2022-11-13 | Southeast Missouri State (332) | 50 | 62 | Missouri (46) | Final | L | -12 |
| 4 | 2022-11-18 | LeMoyne-Owen | 45 | 76 | Southeast Missouri State (272) | Final | W | 31 |
| 5 | 2022-11-26 | Southeast Missouri State (243) | 49 | 66 | Rhode Island (41) | Final | L | -17 |
| 6 | 2022-11-27 | Southeast Missouri State (236) | 41 | 67 | Central Florida (81) | Final | L | -26 |
| 7 | 2022-12-01 | Rust | 60 | 63 | Southeast Missouri State (273) | Final | W | 3 |
| 8 | 2022-12-04 | Southeast Missouri State (273) | 51 | 88 | Kansas (30) | Final | L | -37 |
| 9 | 2022-12-07 | Western Illinois (308) | 55 | 63 | Southeast Missouri State (286) | Final | W | 8 |
| 10 | 2022-12-18 | Southeast Missouri State (256) | 53 | 64 | Evansville (202) | Final | L | -11 |
| 11 | 2022-12-20 | Illinois-Chicago (201) | 55 | 56 | Southeast Missouri State (243) | Final | W | 1 |
| 12 | 2022-12-29 | Southeast Missouri State (234) | 54 | 68 | Southern Indiana (214) | Final | L | -14 |
| 13 | 2022-12-31 | SIU-Edwardsville (327) | 76 | 61 | Southeast Missouri State (234) | Final | L | -15 |
| 14 | 2023-01-05 | Southeast Missouri State (243) | 58 | 77 | Tennessee-Martin (249) | Final | L | -19 |
| 15 | 2023-01-07 | Southeast Missouri State (282) | 45 | 65 | Little Rock (229) | Final | L | -20 |
| 16 | 2023-01-12 | Lindenwood (353) | 45 | 68 | Southeast Missouri State (300) | Final | W | 23 |
| 17 | 2023-01-14 | Southeast Missouri State (300) | 87 | 77 | Morehead State (283) | Final | W | 10 |
| 18 | 2023-01-19 | Tennessee-Martin (249) | 54 | 56 | Southeast Missouri State (243) | Final | W | 2 |
| 19 | 2023-01-21 | Tennessee Tech (164) | 76 | 72 | Southeast Missouri State (286) | Final | L | -4 |
| 20 | 2023-01-26 | Tennessee State (317) | 59 | 77 | Southeast Missouri State (278) | Final | W | 18 |
| 21 | 2023-01-28 | Southeast Missouri State (278) | 57 | 63 | Eastern Illinois (136) | Final | L | -6 |
| 22 | 2023-02-02 | Little Rock (193) | 58 | 39 | Southeast Missouri State (278) | Final | L | -19 |
| 23 | 2023-02-04 | Southeast Missouri State (278) | 65 | 71 | Tennessee Tech (175) | Final | L | -6 |
| 24 | 2023-02-09 | Southeast Missouri State (280) | 90 | 86 | Tennessee State (310) | Final/OT | W | 4 |
| 25 | 2023-02-11 | Morehead State (183) | 55 | 69 | Southeast Missouri State (243) | Final | W | 14 |
| 26 | 2023-02-16 | Eastern Illinois (149) | 57 | 62 | Southeast Missouri State (268) | Final | W | 5 |
| 27 | 2023-02-18 | Southern Indiana (274) | 59 | 63 | Southeast Missouri State (268) | Final | W | 4 |
| 28 | 2023-02-23 | Southeast Missouri State (257) | 67 | 62 | Lindenwood (353) | Final | W | 5 |
| 29 | 2023-02-25 | Southeast Missouri State (257) | 88 | 72 | SIU-Edwardsville (304) | Final | W | 16 |
| 30 | 2023-03-02 | Morehead State (311) | 38 | 77 | Southeast Missouri State (253) | Final | W | 39 |
| 31 | 2023-03-03 | Southeast Missouri State (253) | 35 | 49 | Little Rock (153) | Final | L | -14 |