NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-12-12 | Adrian | 0 | 0 | Holy Cross (167) | Cancelled | - | - |
| 2 | 2021-01-04 | Holy Cross (121) | 54 | 76 | Boston University (284) | Final | L | -22 |
| 3 | 2021-01-05 | Boston University (284) | 72 | 56 | Holy Cross (121) | Final | L | -16 |
| 4 | 2021-01-09 | Holy Cross (121) | 80 | 46 | Army (109) | Final | W | 34 |
| 5 | 2021-01-10 | Army (109) | 42 | 61 | Holy Cross (121) | Final | W | 19 |
| 6 | 2021-01-16 | Colgate (319) | 48 | 77 | Holy Cross (121) | Final | W | 29 |
| 7 | 2021-01-17 | Colgate (319) | 62 | 63 | Holy Cross (121) | Final | W | 1 |
| 8 | 2021-01-23 | Holy Cross (121) | 68 | 87 | Lehigh (189) | Final | L | -19 |
| 9 | 2021-01-24 | Holy Cross (121) | 62 | 83 | Lehigh (189) | Final | L | -21 |
| 10 | 2021-01-30 | Holy Cross (121) | 0 | 0 | Boston University (284) | Postponed | - | - |
| 11 | 2021-01-31 | Boston University (284) | 0 | 0 | Holy Cross (121) | Postponed | - | - |
| 12 | 2021-02-06 | Army (109) | 49 | 61 | Holy Cross (121) | Final | W | 12 |
| 13 | 2021-02-07 | Holy Cross (121) | 42 | 60 | Army (109) | Final | L | -18 |
| 14 | 2021-02-13 | Holy Cross (121) | 61 | 40 | Colgate (319) | Final | W | 21 |
| 15 | 2021-02-14 | Holy Cross (121) | 0 | 0 | Colgate (319) | Cancelled | - | - |
| 16 | 2021-02-17 | Holy Cross (121) | 53 | 71 | Boston University (284) | Final | L | -18 |
| 17 | 2021-02-20 | Boston University (284) | 70 | 58 | Holy Cross (121) | Final | L | -12 |
| 18 | 2021-02-21 | Holy Cross (121) | 60 | 52 | Boston University (284) | Final | W | 8 |
| 19 | 2021-02-24 | Boston University (97) | Holy Cross (185) | Cancelled | - | - | ||
| 20 | 2021-02-27 | Holy Cross (121) | 0 | 0 | Army (109) | Cancelled | - | - |
| 21 | 2021-02-28 | Army (109) | 0 | 0 | Holy Cross (121) | Cancelled | - | - |
| 22 | 2021-03-07 | Holy Cross (173) | 57 | 75 | Lehigh (95) | Final | L | -18 |