Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-08-31 | Alcorn State (148) | 10 | Southern Miss (88) | 38 | Final | W | 28 |
| 2 | 2019-09-07 | Southern Miss (88) | 15 | Mississippi State (13) | 38 | Final | L | -23 |
| 3 | 2019-09-14 | Southern Miss (88) | 47 | Troy (41) | 42 | Final | W | 5 |
| 4 | 2019-09-21 | Southern Miss (88) | 7 | Alabama (2) | 49 | Final | L | -42 |
| 5 | 2019-09-28 | UTEP (122) | 13 | Southern Miss (73) | 31 | Final | W | 18 |
| 6 | 2019-10-12 | North Texas (95) | 27 | Southern Miss (73) | 45 | Final | W | 18 |
| 7 | 2019-10-19 | Southern Miss (68) | 30 | Louisiana Tech (51) | 45 | Final | L | -15 |
| 8 | 2019-10-26 | Southern Miss (73) | 20 | Rice (128) | 6 | Final | W | 14 |
| 9 | 2019-11-09 | UAB (84) | 2 | Southern Miss (77) | 37 | Final | W | 35 |
| 10 | 2019-11-16 | Southern Miss (59) | 36 | UTSA (124) | 17 | Final | W | 19 |
| 11 | 2019-11-23 | Western Kentucky (76) | 28 | Southern Miss (56) | 10 | Final | L | -18 |
| 12 | 2019-11-30 | Southern Miss (72) | 17 | Florida Atlantic (36) | 34 | Final | L | -17 |
| 13 | 2020-01-04 | Southern Miss (76) | 13 | Tulane (46) | 30 | Final | L | -17 |