Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | Kentucky (54) | 24 | Southern Miss (86) | 17 | Final | L | -7 |
| 2 | 2017-09-09 | Southern (150) | 0 | Southern Miss (86) | 45 | Final | W | 45 |
| 3 | 2017-09-16 | Southern Miss | 28 | Louisiana-Monroe | 17 | Final | W | 11 |
| 4 | 2017-09-30 | North Texas (94) | 43 | Southern Miss (50) | 28 | Final | L | -15 |
| 5 | 2017-10-07 | Southern Miss (75) | 31 | UTSA (61) | 29 | Final | W | 2 |
| 6 | 2017-10-14 | UTEP (155) | 0 | Southern Miss (62) | 24 | Final | W | 24 |
| 7 | 2017-10-21 | Southern Miss | 34 | Louisiana Tech | 27 | Final/2OT | W | 7 |
| 8 | 2017-10-28 | UAB (107) | 30 | Southern Miss (59) | 12 | Final | L | -18 |
| 9 | 2017-11-04 | Southern Miss (69) | 10 | Tennessee (82) | 24 | Final | L | -14 |
| 10 | 2017-11-11 | Southern Miss (84) | 43 | Rice (145) | 34 | Final | W | 9 |
| 11 | 2017-11-18 | Charlotte (164) | 21 | Southern Miss (80) | 66 | Final | W | 45 |
| 12 | 2017-11-25 | Southern Miss (78) | 28 | Marshall (60) | 27 | Final | W | 1 |
| 13 | 2017-12-27 | Southern Miss (72) | 13 | Florida State (39) | 42 | Final | L | -29 |