Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Mississippi State (7) | 34 | Southern Miss (113) | 16 | Final | L | -18 |
| 2 | 2015-09-12 | Austin Peay | 6 | Southern Miss | 52 | Final | W | 46 |
| 3 | 2015-09-19 | Southern Miss (95) | 56 | Texas State (86) | 50 | Final | W | 6 |
| 4 | 2015-09-26 | Southern Miss (67) | 28 | Nebraska (61) | 36 | Final | L | -8 |
| 5 | 2015-10-03 | North Texas (125) | 14 | Southern Miss (82) | 49 | Final | W | 35 |
| 6 | 2015-10-09 | Southern Miss (79) | 10 | Marshall (57) | 31 | Final | L | -21 |
| 7 | 2015-10-17 | UTSA (113) | 10 | Southern Miss (99) | 32 | Final | W | 22 |
| 8 | 2015-10-24 | Southern Miss (85) | 44 | Charlotte (117) | 10 | Final | W | 34 |
| 9 | 2015-10-31 | UTEP (115) | 13 | Southern Miss (85) | 34 | Final | W | 21 |
| 10 | 2015-11-14 | Southern Miss (85) | 65 | Rice (106) | 10 | Final | W | 55 |
| 11 | 2015-11-21 | Old Dominion (101) | 31 | Southern Miss (83) | 56 | Final | W | 25 |
| 12 | 2015-11-28 | Southern Miss | 58 | Louisiana Tech | 24 | Final | W | 34 |
| 13 | 2015-12-05 | Southern Miss | 28 | Western Kentucky | 45 | Final | L | -17 |
| 14 | 2015-12-26 | Washington (53) | 44 | Southern Miss (84) | 31 | Final | L | -13 |