Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Elon | 14 | South Florida | 34 | Final | W | 20 |
| 2 | 2018-09-08 | Georgia Tech | 38 | South Florida | 49 | Final | W | 11 |
| 3 | 2018-09-15 | South Florida | 25 | Illinois | 19 | Final | W | 6 |
| 4 | 2018-09-22 | East Carolina | 13 | South Florida | 20 | Final | W | 7 |
| 5 | 2018-10-06 | South Florida (25) | 58 | Massachusetts (106) | 42 | Final | W | 16 |
| 6 | 2018-10-12 | South Florida (20) | 25 | Tulsa (115) | 24 | Final | W | 1 |
| 7 | 2018-10-20 | Connecticut (133) | 30 | South Florida (25) | 38 | Final | W | 8 |
| 8 | 2018-10-27 | South Florida (32) | 36 | Houston (44) | 57 | Final | L | -21 |
| 9 | 2018-11-03 | Tulane (100) | 41 | South Florida (49) | 15 | Final | L | -26 |
| 10 | 2018-11-10 | South Florida (67) | 23 | Cincinnati (19) | 35 | Final | L | -12 |
| 11 | 2018-11-17 | South Florida (76) | 17 | Temple (48) | 27 | Final | L | -10 |
| 12 | 2018-11-23 | Central Florida (6) | 38 | South Florida (85) | 10 | Final | L | -28 |
| 13 | 2018-12-20 | Marshall (71) | 38 | South Florida (87) | 20 | Final | L | -18 |