Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-03 | South Carolina State | 8 | Southern | 14 | Final | L | -6 |
| 2 | 2017-09-09 | Charleston Southern | 0 | South Carolina State | 0 | Postponed | - | - |
| 3 | 2017-09-16 | Johnson C Smith | 0 | South Carolina State | 41 | Final | W | 41 |
| 4 | 2017-09-21 | South Carolina State | 28 | North Carolina Central | 33 | Final | L | -5 |
| 5 | 2017-09-30 | North Carolina A&T | 21 | South Carolina State | 7 | Final | L | -14 |
| 6 | 2017-10-06 | Morgan State | 14 | South Carolina State | 35 | Final | W | 21 |
| 7 | 2017-10-14 | South Carolina State | 9 | Bethune-Cookman | 12 | Final | L | -3 |
| 8 | 2017-10-21 | South Carolina State | 14 | Delaware State | 17 | Final | L | -3 |
| 9 | 2017-10-28 | Howard | 28 | South Carolina State | 20 | Final | L | -8 |
| 10 | 2017-11-11 | Hampton | 15 | South Carolina State | 33 | Final | W | 18 |
| 11 | 2017-11-18 | South Carolina State | 10 | Savannah State | 34 | Final | L | -24 |