Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-25 | Prairie View A&M | 28 | Rice | 31 | Final | L | -3 |
| 2 | 2018-09-02 | Prairie View A&M | 40 | North Carolina Central | 24 | Final | W | 16 |
| 3 | 2018-09-08 | Prairie View A&M | 32 | Sam Houston State | 41 | Final | L | -9 |
| 4 | 2018-09-15 | Prairie View A&M | 17 | UNLV | 46 | Final | L | -29 |
| 5 | 2018-09-22 | Prairie View A&M | 62 | Arkansas-Pine Bluff | 13 | Final | W | 49 |
| 6 | 2018-09-29 | Prairie View A&M (191) | 22 | Grambling (203) | 16 | Final | W | 6 |
| 7 | 2018-10-13 | Southern (208) | 38 | Prairie View A&M (167) | 0 | Final | L | -38 |
| 8 | 2018-10-27 | Alcorn State (160) | 27 | Prairie View A&M (186) | 13 | Final | L | -14 |
| 9 | 2018-11-03 | Prairie View A&M (193) | 28 | Jackson State (224) | 34 | Final | L | -6 |
| 10 | 2018-11-17 | Alabama State (228) | 13 | Prairie View A&M (210) | 66 | Final | W | 53 |
| 11 | 2018-11-24 | Texas Southern (244) | 14 | Prairie View A&M (196) | 60 | Final | W | 46 |