Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2026-09-06 | Louisville (35) | Ole Miss (7) | Scheduled - 6:30 PM | - | - | ||
| 2 | 2026-09-11 | Villanova | Louisville | Scheduled - 7:00 PM | - | - | ||
| 3 | 2026-09-19 | SMU | Louisville | Scheduled - 3:30 PM | - | - | ||
| 4 | 2026-09-26 | Wake Forest | Louisville | Scheduled - TBD | - | - | ||
| 5 | 2026-10-03 | Louisville | North Carolina State | Scheduled - TBD | - | - | ||
| 6 | 2026-10-09 | Florida State | Louisville | Scheduled - 7:00 PM | - | - | ||
| 7 | 2026-10-17 | Louisville | Syracuse | Scheduled - TBD | - | - | ||
| 8 | 2026-10-31 | Stanford | Louisville | Scheduled - TBD | - | - | ||
| 9 | 2026-11-07 | Louisville | Georgia Tech | Scheduled - TBD | - | - | ||
| 10 | 2026-11-14 | Louisville | North Carolina | Scheduled - TBD | - | - | ||
| 11 | 2026-11-21 | Pittsburgh | Louisville | Scheduled - TBD | - | - | ||
| 12 | 2026-11-28 | Louisville | Kentucky | Scheduled - TBD | - | - |