Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2023-09-01 | Louisville (27) | 39 | Georgia Tech (81) | 34 | Final | W | 5 |
| 2 | 2023-09-07 | Murray State (241) | 0 | Louisville (27) | 56 | Final | W | 56 |
| 3 | 2023-09-16 | Louisville (26) | 21 | Indiana (92) | 14 | Final | W | 7 |
| 4 | 2023-09-23 | Boston College (128) | 28 | Louisville (17) | 56 | Final | W | 28 |
| 5 | 2023-09-29 | Louisville (18) | 13 | North Carolina State (70) | 10 | Final | W | 3 |
| 6 | 2023-10-07 | Notre Dame (15) | 20 | Louisville (6) | 33 | Final | W | 13 |
| 7 | 2023-10-14 | Louisville (22) | 21 | Pittsburgh (85) | 38 | Final | L | -17 |
| 8 | 2023-10-28 | Duke (27) | 0 | Louisville (17) | 23 | Final | W | 23 |
| 9 | 2023-11-04 | Virginia Tech (66) | 3 | Louisville (12) | 34 | Final | W | 31 |
| 10 | 2023-11-09 | Virginia (102) | 24 | Louisville (14) | 31 | Final | W | 7 |
| 11 | 2023-11-18 | Louisville (13) | 38 | Miami (35) | 31 | Final | W | 7 |
| 12 | 2023-11-25 | Kentucky (43) | 38 | Louisville (17) | 31 | Final | L | -7 |
| 13 | 2023-12-02 | Louisville (18) | 6 | Florida State (3) | 16 | Final | L | -10 |
| 14 | 2023-12-27 | Louisville (18) | 28 | USC (20) | 42 | Final | L | -14 |