Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2023-09-02 | Northern Iowa (160) | 9 | Iowa State (67) | 30 | Final | W | 21 |
| 2 | 2023-09-09 | Iowa (54) | 20 | Iowa State (67) | 13 | Final | L | -7 |
| 3 | 2023-09-16 | Iowa State (105) | 7 | Ohio (68) | 10 | Final | L | -3 |
| 4 | 2023-09-23 | Oklahoma State (110) | 27 | Iowa State (89) | 34 | Final | W | 7 |
| 5 | 2023-09-30 | Iowa State (85) | 20 | Oklahoma (3) | 50 | Final | L | -30 |
| 6 | 2023-10-07 | TCU (63) | 14 | Iowa State (59) | 27 | Final | W | 13 |
| 7 | 2023-10-14 | Iowa State (40) | 30 | Cincinnati (84) | 10 | Final | W | 20 |
| 8 | 2023-10-28 | Iowa State (47) | 30 | Baylor (94) | 18 | Final | W | 12 |
| 9 | 2023-11-04 | Kansas (19) | 28 | Iowa State (54) | 21 | Final | L | -7 |
| 10 | 2023-11-11 | Iowa State (44) | 45 | BYU (85) | 13 | Final | W | 32 |
| 11 | 2023-11-18 | Texas (8) | 26 | Iowa State (44) | 16 | Final | L | -10 |
| 12 | 2023-11-25 | Iowa State (36) | 42 | Kansas State (18) | 35 | Final | W | 7 |
| 13 | 2023-12-29 | Memphis (32) | 36 | Iowa State (40) | 26 | Final | L | -10 |