Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-08-31 | East Carolina (127) | 6 | North Carolina State (32) | 34 | Final | L | -28 |
| 2 | 2019-09-07 | Gardner-Webb (236) | 9 | East Carolina (127) | 48 | Final | W | 39 |
| 3 | 2019-09-14 | East Carolina (127) | 10 | Navy (111) | 42 | Final | L | -32 |
| 4 | 2019-09-21 | William & Mary (193) | 7 | East Carolina (127) | 19 | Final | W | 12 |
| 5 | 2019-09-28 | East Carolina (104) | 24 | Old Dominion (105) | 21 | Final | W | 3 |
| 6 | 2019-10-03 | Temple (59) | 27 | East Carolina (99) | 17 | Final | L | -10 |
| 7 | 2019-10-19 | East Carolina (102) | 28 | Central Florida (31) | 41 | Final | L | -13 |
| 8 | 2019-10-26 | South Florida (92) | 45 | East Carolina (111) | 20 | Final | L | -25 |
| 9 | 2019-11-02 | Cincinnati (10) | 46 | East Carolina (119) | 43 | Final | L | -3 |
| 10 | 2019-11-09 | East Carolina (116) | 51 | SMU (19) | 59 | Final | L | -8 |
| 11 | 2019-11-23 | East Carolina (116) | 31 | Connecticut (131) | 24 | Final | W | 7 |
| 12 | 2019-11-30 | Tulsa (80) | 49 | East Carolina (114) | 24 | Final | L | -25 |