Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Kentucky Christian | 7 | Duquesne | 47 | Final | W | 40 |
| 2 | 2015-09-12 | Duquesne | 26 | Bucknell | 7 | Final | W | 19 |
| 3 | 2015-09-19 | Duquesne | 13 | Dayton | 24 | Final | L | -11 |
| 4 | 2015-09-26 | Duquesne | 14 | Albany | 17 | Final | L | -3 |
| 5 | 2015-10-03 | Central Connecticut State | 10 | Duquesne | 27 | Final | W | 17 |
| 6 | 2015-10-10 | Alderson-Brodus | 18 | Duquesne | 53 | Final | W | 35 |
| 7 | 2015-10-17 | Duquesne | 17 | Bryant | 38 | Final | L | -21 |
| 8 | 2015-10-24 | Duquesne | 16 | Robert Morris | 7 | Final | W | 9 |
| 9 | 2015-10-31 | Wagner | 17 | Duquesne | 35 | Final | W | 18 |
| 10 | 2015-11-07 | Duquesne | 41 | Sacred Heart | 14 | Final | W | 27 |
| 11 | 2015-11-28 | Duquesne | 49 | William & Mary | 52 | Final | L | -3 |