Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-08-31 | Alabama (2) | 42 | Duke (39) | 3 | Final | L | -39 |
| 2 | 2019-09-07 | North Carolina A&T (130) | 13 | Duke (39) | 45 | Final | W | 32 |
| 3 | 2019-09-14 | Duke (39) | 41 | Middle Tennessee (64) | 18 | Final | W | 23 |
| 4 | 2019-09-27 | Duke (61) | 45 | Virginia Tech (84) | 10 | Final | W | 35 |
| 5 | 2019-10-05 | Pittsburgh (51) | 33 | Duke (45) | 30 | Final | L | -3 |
| 6 | 2019-10-12 | Georgia Tech (119) | 23 | Duke (52) | 41 | Final | W | 18 |
| 7 | 2019-10-19 | Duke (45) | 14 | Virginia (42) | 48 | Final | L | -34 |
| 8 | 2019-10-26 | Duke (51) | 17 | North Carolina (49) | 20 | Final | L | -3 |
| 9 | 2019-11-09 | Notre Dame (20) | 38 | Duke (66) | 7 | Final | L | -31 |
| 10 | 2019-11-16 | Syracuse (105) | 49 | Duke (69) | 6 | Final | L | -43 |
| 11 | 2019-11-23 | Duke (85) | 27 | Wake Forest (34) | 39 | Final | L | -12 |
| 12 | 2019-11-30 | Miami (44) | 17 | Duke (87) | 27 | Final | W | 10 |