Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | North Carolina Central | 7 | Duke | 60 | Final | W | 53 |
| 2 | 2017-09-09 | Northwestern (49) | 17 | Duke (85) | 41 | Final | W | 24 |
| 3 | 2017-09-16 | Baylor (57) | 20 | Duke (85) | 34 | Final | W | 14 |
| 4 | 2017-09-23 | Duke (85) | 27 | North Carolina (41) | 17 | Final | W | 10 |
| 5 | 2017-09-29 | Miami (28) | 31 | Duke (24) | 6 | Final | L | -25 |
| 6 | 2017-10-07 | Duke (42) | 21 | Virginia (50) | 28 | Final | L | -7 |
| 7 | 2017-10-14 | Florida State (53) | 17 | Duke (52) | 10 | Final | L | -7 |
| 8 | 2017-10-21 | Pittsburgh | 24 | Duke | 17 | Final | L | -7 |
| 9 | 2017-10-28 | Duke (78) | 3 | Virginia Tech (16) | 24 | Final | L | -21 |
| 10 | 2017-11-11 | Duke (79) | 16 | Army (42) | 21 | Final | L | -5 |
| 11 | 2017-11-18 | Georgia Tech (42) | 20 | Duke (82) | 43 | Final | W | 23 |
| 12 | 2017-11-25 | Duke (67) | 31 | Wake Forest (29) | 23 | Final | W | 8 |
| 13 | 2017-12-26 | Duke | 36 | Northern Illinois | 14 | Final | W | 22 |