Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Southeast Missouri State (158) | 24 | Arkansas State (89) | 42 | Final | L | -18 |
| 2 | 2025-09-06 | North Alabama (205) | 0 | Southeast Missouri State (158) | 0 | Scheduled – 6:00 PM | – | – |
| 3 | 2025-09-13 | Southeast Missouri State (158) | 0 | North Dakota State (69) | 0 | Scheduled – 2:30 PM | – | – |
| 4 | 2025-09-20 | Southern Illinois (184) | 0 | Southeast Missouri State (158) | 0 | Scheduled – 6:00 PM | – | – |
| 5 | 2025-09-27 | Southeast Missouri State (158) | 0 | Tennessee-Martin (137) | 0 | Scheduled – 6:00 PM | – | – |
| 6 | 2025-10-11 | Tennessee State (171) | 0 | Southeast Missouri State (158) | 0 | Scheduled – 3:00 PM | – | – |
| 7 | 2025-10-18 | Eastern Illinois (226) | 0 | Southeast Missouri State (158) | 0 | Scheduled – 2:00 PM | – | – |
| 8 | 2025-10-25 | Southeast Missouri State (158) | 0 | Tennessee Tech (164) | 0 | Scheduled – 12:00 PM | – | – |
| 9 | 2025-11-01 | Charleston Southern (250) | 0 | Southeast Missouri State (158) | 0 | Scheduled – 1:00 PM | – | – |
| 10 | 2025-11-08 | Southeast Missouri State (158) | 0 | Gardner-Webb (201) | 0 | Scheduled – 1:30 PM | – | – |
| 11 | 2025-11-15 | Southeast Missouri State (158) | 0 | Western Illinois (223) | 0 | Scheduled – 1:00 PM | – | – |
| 12 | 2025-11-22 | Lindenwood (193) | 0 | Southeast Missouri State (158) | 0 | Scheduled – 1:00 PM | – | – |