Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-23 | Incarnate Word (131) | 6 | Nicholls State (207) | 20 | Final | W | 14 |
| 2 | 2025-08-30 | Nicholls State (207) | 20 | Troy (112) | 38 | Final | L | -18 |
| 3 | 2025-09-06 | West Georgia (221) | 0 | Nicholls State (207) | 0 | Scheduled – 6:00 PM | – | – |
| 4 | 2025-09-20 | Nicholls State (207) | 0 | Texas State (58) | 0 | Scheduled – 7:00 PM | – | – |
| 5 | 2025-09-27 | Nicholls State (207) | 0 | Eastern Kentucky (162) | 0 | Scheduled – 6:00 PM | – | – |
| 6 | 2025-10-04 | Nicholls State (207) | 0 | Lamar (181) | 0 | Scheduled – 3:00 PM | – | – |
| 7 | 2025-10-18 | Nicholls State (207) | 0 | Stephen F. Austin (163) | 0 | Scheduled – 6:00 PM | – | – |
| 8 | 2025-10-24 | McNeese (185) | 0 | Nicholls State (207) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-01 | Houston Christian (200) | 0 | Nicholls State (207) | 0 | Scheduled – 3:00 PM | – | – |
| 10 | 2025-11-08 | Nicholls State (207) | 0 | UTRGV | 0 | Scheduled – 6:00 PM | – | – |
| 11 | 2025-11-14 | Northwestern State (263) | 0 | Nicholls State (207) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-20 | Nicholls State (207) | 0 | Southeastern Louisiana (155) | 0 | Scheduled – 6:00 PM | – | – |