Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Rice (101) | 14 | Louisiana (54) | 12 | Final | L | -2 |
| 2 | 2025-09-06 | McNeese (185) | 0 | Louisiana (54) | 0 | Scheduled – 7:00 PM | – | – |
| 3 | 2025-09-13 | Louisiana (54) | 0 | Missouri (23) | 0 | Scheduled – 3:00 PM | – | – |
| 4 | 2025-09-20 | Louisiana (54) | 0 | Eastern Michigan (117) | 0 | Scheduled – 3:30 PM | – | – |
| 5 | 2025-09-26 | Marshall (37) | 0 | Louisiana (54) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-11 | Louisiana (54) | 0 | James Madison (56) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-17 | Southern Miss (157) | 0 | Louisiana (54) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-24 | Louisiana (54) | 0 | Troy (112) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-10-31 | Louisiana (54) | 0 | South Alabama (68) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-07 | Texas State (58) | 0 | Louisiana (54) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-20 | Louisiana (54) | 0 | Arkansas State (89) | 0 | Scheduled – 6:30 PM | – | – |
| 12 | 2025-11-28 | Louisiana-Monroe (106) | 0 | Louisiana (54) | 0 | Scheduled – TBD | – | – |