Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Eastern Kentucky (162) | 17 | Louisville (20) | 51 | Final | L | -34 |
| 2 | 2025-09-06 | Houston Christian (200) | 0 | Eastern Kentucky (162) | 0 | Scheduled – 6:00 PM | – | – |
| 3 | 2025-09-13 | Eastern Kentucky (162) | 0 | Marshall (37) | 0 | Scheduled – 6:00 PM | – | – |
| 4 | 2025-09-20 | Eastern Kentucky (162) | 0 | West Georgia (221) | 0 | Scheduled – 6:00 PM | – | – |
| 5 | 2025-09-27 | Nicholls State (207) | 0 | Eastern Kentucky (162) | 0 | Scheduled – 6:00 PM | – | – |
| 6 | 2025-10-11 | Austin Peay (203) | 0 | Eastern Kentucky (162) | 0 | Scheduled – 6:00 PM | – | – |
| 7 | 2025-10-18 | Eastern Kentucky (162) | 0 | North Alabama (205) | 0 | Scheduled – 6:00 PM | – | – |
| 8 | 2025-10-25 | Tarleton State (138) | 0 | Eastern Kentucky (162) | 0 | Scheduled – 3:00 PM | – | – |
| 9 | 2025-11-01 | Eastern Kentucky (162) | 0 | Central Arkansas (178) | 0 | Scheduled – 4:00 PM | – | – |
| 10 | 2025-11-08 | Southern Utah (153) | 0 | Eastern Kentucky (162) | 0 | Scheduled – 3:00 PM | – | – |
| 11 | 2025-11-15 | Abilene Christian (147) | 0 | Eastern Kentucky (162) | 0 | Scheduled – 3:00 PM | – | – |
| 12 | 2025-11-22 | Eastern Kentucky (162) | 0 | Utah Tech (245) | 0 | Scheduled – 2:00 PM | – | – |