Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2026-11-02 | Chattanooga | Louisville | Scheduled - 9:00 PM | - | - | ||
| 2 | 2026-11-07 | Morehead State | Louisville | Scheduled - TBD | - | - | ||
| 3 | 2026-11-15 | Louisville | Memphis | Scheduled - 12:00 PM | - | - | ||
| 4 | 2026-11-19 | Stetson | Louisville | Scheduled - 8:00 PM | - | - | ||
| 5 | 2026-11-24 | Louisville | Texas Tech | Scheduled - 5:00 PM | - | - | ||
| 6 | 2026-12-01 | Texas | Louisville | Scheduled - 9:00 PM | - | - | ||
| 7 | 2026-12-05 | Louisville | Michigan | Scheduled - 12:00 PM | - | - | ||
| 8 | 2026-12-12 | Louisville | Kentucky | Scheduled - 4:00 PM | - | - | ||
| 9 | 2026-12-16 | Long Island | Louisville | Scheduled - 9:00 PM | - | - | ||
| 10 | 2026-12-19 | Eastern Michigan | Louisville | Scheduled - 1:30 PM | - | - | ||
| 11 | 2026-12-30 | Louisville | Virginia Tech | Scheduled - 8:00 PM | - | - | ||
| 12 | 2026-12-31 | Louisville | Boston College | Scheduled - TBD | - | - | ||
| 13 | 2027-01-02 | Stanford | Louisville | Scheduled - 6:00 PM | - | - | ||
| 14 | 2027-01-05 | North Carolina | Louisville | Scheduled - 9:00 PM | - | - | ||
| 15 | 2027-01-09 | Louisville | SMU | Scheduled - 1:15 PM | - | - | ||
| 16 | 2027-01-13 | California | Louisville | Scheduled - 7:00 PM | - | - | ||
| 17 | 2027-01-16 | Louisville | Syracuse | Scheduled - 2:00 PM | - | - | ||
| 18 | 2027-01-19 | Miami | Louisville | Scheduled - 7:00 PM | - | - | ||
| 19 | 2027-01-23 | Louisville | Baylor | Scheduled - TBD | - | - | ||
| 20 | 2027-01-27 | Louisville | Boston College | Scheduled - 7:00 PM | - | - | ||
| 21 | 2027-01-30 | Louisville | Georgia Tech | Scheduled - 12:00 PM | - | - | ||
| 22 | 2027-02-02 | Pittsburgh | Louisville | Scheduled - 9:00 PM | - | - | ||
| 23 | 2027-02-06 | Wake Forest | Louisville | Scheduled - 3:00 PM | - | - | ||
| 24 | 2027-02-08 | Louisville | North Carolina | Scheduled - 6:00 PM | - | - | ||
| 25 | 2027-02-13 | SMU | Louisville | Scheduled - 12:00 PM | - | - | ||
| 26 | 2027-02-15 | Louisville | Virginia | Scheduled - 7:00 PM | - | - | ||
| 27 | 2027-02-21 | Louisville | Florida State | Scheduled - 4:00 PM | - | - | ||
| 28 | 2027-02-24 | Duke | Louisville | Scheduled - 7:00 PM | - | - | ||
| 29 | 2027-03-02 | Louisville | North Carolina State | Scheduled - 7:00 PM | - | - | ||
| 30 | 2027-03-06 | Clemson | Louisville | Scheduled - 12:00 PM | - | - |