Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-11-10 | Iowa State (24) | 59 | 74 | Missouri (195) | Final | L | -15 |
| 2 | 2017-11-13 | Milwaukee (263) | 74 | 56 | Iowa State (24) | Final | L | -18 |
| 3 | 2017-11-16 | Iowa State (24) | 104 | 98 | Appalachian State (259) | Final | W | 6 |
| 4 | 2017-11-17 | Iowa State (24) | 80 | 78 | Tulsa (130) | Final | W | 2 |
| 5 | 2017-11-19 | Boise State (96) | 64 | 75 | Iowa State (24) | Final | W | 11 |
| 6 | 2017-11-25 | Western Illinois (85) | 45 | 70 | Iowa State (115) | Final | W | 25 |
| 7 | 2017-12-04 | Northern Illinois (193) | 80 | 94 | Iowa State (88) | Final | W | 14 |
| 8 | 2017-12-07 | Iowa (160) | 78 | 84 | Iowa State (84) | Final | W | 6 |
| 9 | 2017-12-10 | Alcorn State (332) | 58 | 78 | Iowa State (84) | Final | W | 20 |
| 10 | 2017-12-16 | Iowa State (58) | 76 | 65 | Northern Iowa (28) | Final | W | 11 |
| 11 | 2017-12-20 | Maryland-Eastern Shore (332) | 49 | 55 | Iowa State (41) | Final | W | 6 |
| 12 | 2017-12-29 | Kansas State (55) | 91 | 75 | Iowa State (64) | Final | L | -16 |
| 13 | 2018-01-01 | Texas (30) | 74 | 70 | Iowa State (64) | Final/OT | L | -4 |
| 14 | 2018-01-06 | Iowa State (73) | 87 | 96 | Oklahoma State (43) | Final/OT | L | -9 |
| 15 | 2018-01-09 | Iowa State (94) | 78 | 83 | Kansas (10) | Final | L | -5 |
| 16 | 2018-01-13 | Baylor (38) | 65 | 75 | Iowa State (94) | Final | W | 10 |
| 17 | 2018-01-17 | Iowa State (85) | 73 | 96 | TCU (23) | Final | L | -23 |
| 18 | 2018-01-20 | Texas Tech (4) | 52 | 70 | Iowa State (85) | Final | W | 18 |
| 19 | 2018-01-22 | Iowa State (85) | 57 | 73 | Texas (39) | Final | L | -16 |
| 20 | 2018-01-27 | Tennessee (17) | 68 | 45 | Iowa State (74) | Final | L | -23 |
| 21 | 2018-01-31 | West Virginia (12) | 77 | 93 | Iowa State (86) | Final | W | 16 |
| 22 | 2018-02-03 | Iowa State (86) | 67 | 81 | Baylor (67) | Final | L | -14 |
| 23 | 2018-02-07 | Iowa State (82) | 58 | 76 | Texas Tech (10) | Final | L | -18 |
| 24 | 2018-02-10 | Oklahoma (22) | 80 | 88 | Iowa State (82) | Final | W | 8 |
| 25 | 2018-02-13 | Kansas (10) | 83 | 77 | Iowa State (75) | Final | L | -6 |
| 26 | 2018-02-17 | Iowa State (75) | 66 | 78 | Kansas State (41) | Final | L | -12 |
| 27 | 2018-02-21 | TCU (24) | 89 | 83 | Iowa State (84) | Final | L | -6 |
| 28 | 2018-02-24 | Iowa State (84) | 70 | 85 | West Virginia (14) | Final | L | -15 |
| 29 | 2018-02-27 | Oklahoma State (60) | 80 | 71 | Iowa State (85) | Final | L | -9 |
| 30 | 2018-03-02 | Iowa State (85) | 60 | 81 | Oklahoma (34) | Final | L | -21 |
| 31 | 2018-03-07 | Iowa State (90) | 64 | 68 | Texas (38) | Final | L | -4 |