Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | Southern Miss (304) | 79 | 85 | Buffalo (330) | Final | L | -6 |
| 2 | 2025-11-06 | Tougaloo | 57 | 93 | Southern Miss (304) | Final | W | 36 |
| 3 | 2025-11-09 | Southern Miss (304) | 79 | 83 | South Carolina (84) | Final/OT | L | -4 |
| 4 | 2025-11-13 | Southern Miss (304) | 70 | 75 | Grambling (336) | Final | L | -5 |
| 5 | 2025-11-18 | William Carey | Southern Miss | Scheduled – 7:00 PM | – | – | ||
| 6 | 2025-11-22 | Southern Miss | North Florida | Scheduled – 8:00 PM | – | – | ||
| 7 | 2025-11-23 | Southern Miss | Prairie View A&M | Scheduled – 11:00 PM | – | – | ||
| 8 | 2025-12-03 | Southern Miss | Radford | Scheduled – 7:00 PM | – | – | ||
| 9 | 2025-12-06 | Southern Miss | Miami | Scheduled – 12:00 PM | – | – | ||
| 10 | 2025-12-08 | Grambling | Southern Miss | Scheduled – 7:00 PM | – | – | ||
| 11 | 2025-12-13 | Southern Miss | Ole Miss | Scheduled – 2:00 PM | – | – | ||
| 12 | 2025-12-18 | Louisiana | Southern Miss | Scheduled – 7:30 PM | – | – | ||
| 13 | 2025-12-20 | Arkansas State | Southern Miss | Scheduled – 3:30 PM | – | – | ||
| 14 | 2025-12-29 | Southern Miss | LSU | Scheduled – 7:00 PM | – | – | ||
| 15 | 2026-01-01 | Southern Miss | Louisiana-Monroe | Scheduled – 4:00 PM | – | – | ||
| 16 | 2026-01-03 | Southern Miss | Louisiana | Scheduled – 12:00 PM | – | – | ||
| 17 | 2026-01-08 | Texas State | Southern Miss | Scheduled – 7:00 PM | – | – | ||
| 18 | 2026-01-10 | Louisiana-Monroe | Southern Miss | Scheduled – 2:00 PM | – | – | ||
| 19 | 2026-01-14 | Southern Miss | Troy | Scheduled – 6:00 PM | – | – | ||
| 20 | 2026-01-17 | Southern Miss | Texas State | Scheduled – 3:30 PM | – | – | ||
| 21 | 2026-01-22 | Southern Miss | Georgia State | Scheduled – 7:00 PM | – | – | ||
| 22 | 2026-01-24 | Southern Miss | Coastal Carolina | Scheduled – 1:00 PM | – | – | ||
| 23 | 2026-01-29 | Appalachian State | Southern Miss | Scheduled – 7:00 PM | – | – | ||
| 24 | 2026-01-31 | James Madison | Southern Miss | Scheduled – 2:00 PM | – | – | ||
| 25 | 2026-02-04 | Southern Miss | Marshall | Scheduled – 7:00 PM | – | – | ||
| 26 | 2026-02-12 | South Alabama | Southern Miss | Scheduled – 7:30 PM | – | – | ||
| 27 | 2026-02-14 | Troy | Southern Miss | Scheduled – 7:30 PM | – | – | ||
| 28 | 2026-02-21 | Old Dominion | Southern Miss | Scheduled – 2:00 PM | – | – | ||
| 29 | 2026-02-24 | Southern Miss | Arkansas State | Scheduled – 7:30 PM | – | – | ||
| 30 | 2026-02-27 | Southern Miss | South Alabama | Scheduled – 7:30 PM | – | – |