Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Southeast Missouri State (226) | 60 | 88 | Bradley (113) | Final | L | -28 |
| 2 | 2024-11-10 | Southeast Missouri State (343) | 76 | 85 | Vanderbilt (78) | Final | L | -9 |
| 3 | 2024-11-13 | Crowley's Ridge | 38 | 93 | Southeast Missouri State (258) | Final | W | 55 |
| 4 | 2024-11-17 | Chattanooga (220) | 87 | 82 | Southeast Missouri State (317) | Final | L | -5 |
| 5 | 2024-11-21 | Southeast Missouri State (257) | 77 | 73 | Central Arkansas (348) | Final (OT) | W | 4 |
| 6 | 2024-11-22 | UNC-Asheville (194) | 72 | 64 | Southeast Missouri State (292) | Final | L | -8 |
| 7 | 2024-11-30 | UMKC (310) | 59 | 80 | Southeast Missouri State (232) | Final | W | 21 |
| 8 | 2024-12-05 | Southeast Missouri State (266) | 60 | 78 | Lipscomb (129) | Final | L | -18 |
| 9 | 2024-12-08 | Southeast Missouri State (291) | 53 | 73 | Murray State (98) | Final | L | -20 |
| 10 | 2024-12-15 | Saint Mary-of-the-Woods | 56 | 93 | Southeast Missouri State (283) | Final | W | 37 |
| 11 | 2024-12-19 | Eastern Illinois (331) | 72 | 79 | Southeast Missouri State (253) | Final | W | 7 |
| 12 | 2024-12-21 | SIU-Edwardsville (266) | 64 | 80 | Southeast Missouri State (227) | Final | W | 16 |
| 13 | 2024-12-29 | Westminster College | 39 | 88 | Southeast Missouri State (217) | Final | W | 49 |
| 14 | 2025-01-02 | Southeast Missouri State (204) | 67 | 65 | Tennessee State (344) | Final | W | 2 |
| 15 | 2025-01-04 | Southeast Missouri State (224) | 63 | 66 | Tennessee-Martin (292) | Final | L | -3 |
| 16 | 2025-01-09 | Southern Indiana (310) | 66 | 77 | Southeast Missouri State (212) | Final | W | 11 |
| 17 | 2025-01-11 | Morehead State (246) | 67 | 56 | Southeast Missouri State (231) | Final | L | -11 |
| 18 | 2025-01-14 | Little Rock (218) | 73 | 71 | Southeast Missouri State (244) | Final | L | -2 |
| 19 | 2025-01-16 | Southeast Missouri State (229) | 77 | 70 | Tennessee Tech (273) | Final | W | 7 |
| 20 | 2025-01-23 | Southeast Missouri State (242) | 68 | 72 | Lindenwood (287) | Final | L | -4 |
| 21 | 2025-01-25 | Southeast Missouri State (230) | 72 | 51 | Western Illinois (337) | Final | W | 21 |
| 22 | 2025-01-30 | Tennessee-Martin (293) | 79 | 90 | Southeast Missouri State (226) | Final | W | 11 |
| 23 | 2025-02-01 | Tennessee State (284) | 87 | 89 | Southeast Missouri State (225) | Final (OT) | W | 2 |
| 24 | 2025-02-06 | Southeast Missouri State (217) | 80 | 51 | Morehead State (247) | Final | W | 29 |
| 25 | 2025-02-08 | Southeast Missouri State (214) | 79 | 74 | Southern Indiana (318) | Final | W | 5 |
| 26 | 2025-02-11 | Southeast Missouri State (202) | 57 | 45 | Little Rock (214) | Final | W | 12 |
| 27 | 2025-02-15 | Tennessee Tech (287) | 69 | 83 | Southeast Missouri State (193) | Final | W | 14 |
| 28 | 2025-02-20 | Western Illinois (337) | 66 | 87 | Southeast Missouri State (185) | Final | W | 21 |
| 29 | 2025-02-22 | Lindenwood (279) | 58 | 74 | Southeast Missouri State (180) | Final | W | 16 |
| 30 | 2025-02-27 | Southeast Missouri State (172) | 83 | 68 | SIU-Edwardsville (219) | Final | W | 15 |
| 31 | 2025-03-01 | Southeast Missouri State (226) | 58 | 73 | Eastern Illinois (314) | Final | L | -15 |
| 32 | 2025-03-07 | Little Rock (232) | 59 | 78 | Southeast Missouri State (175) | Final | W | 19 |
| 33 | 2025-03-08 | SIU-Edwardsville (196) | 69 | 48 | Southeast Missouri State (183) | Final | L | -21 |