Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-11-06 | Southeast Missouri State (257) | 65 | 75 | Saint Louis (133) | Final | L | -10 |
| 2 | 2018-11-10 | Southeast Missouri State (257) | 57 | 68 | Bradley (121) | Final | L | -11 |
| 3 | 2018-11-12 | Quincy | 66 | 102 | Southeast Missouri State (257) | Final | W | 36 |
| 4 | 2018-11-16 | Southeast Missouri State (305) | 77 | 71 | Jacksonville (328) | Final | W | 6 |
| 5 | 2018-11-17 | Chattanooga (178) | 42 | 63 | Southeast Missouri State (305) | Final | W | 21 |
| 6 | 2018-11-19 | Southeast Missouri State (305) | 58 | 79 | South Alabama (247) | Final | L | -21 |
| 7 | 2018-11-27 | Missouri S&T | 69 | 72 | Southeast Missouri State (238) | Final | W | 3 |
| 8 | 2018-12-01 | Western Illinois (298) | 70 | 63 | Southeast Missouri State (238) | Final | L | -7 |
| 9 | 2018-12-04 | Southeast Missouri State (274) | 77 | 57 | Mississippi Valley State (331) | Final | W | 20 |
| 10 | 2018-12-08 | Southern Illinois (107) | 83 | 73 | Southeast Missouri State (274) | Final | L | -10 |
| 11 | 2018-12-15 | Southeast Missouri State (262) | 74 | 86 | The Citadel (90) | Final | L | -12 |
| 12 | 2018-12-17 | Southeast Missouri State (262) | 68 | 85 | Florida State (16) | Final | L | -17 |
| 13 | 2018-12-21 | Abilene Christian (121) | 70 | 68 | Southeast Missouri State (274) | Final | L | -2 |
| 14 | 2019-01-03 | Southeast Missouri State (280) | 88 | 94 | SIU-Edwardsville (312) | Final | L | -6 |
| 15 | 2019-01-05 | Tennessee-Martin (295) | 69 | 74 | Southeast Missouri State (280) | Final/OT | W | 5 |
| 16 | 2019-01-10 | Austin Peay (110) | 78 | 60 | Southeast Missouri State (289) | Final | L | -18 |
| 17 | 2019-01-12 | Murray State (56) | 85 | 67 | Southeast Missouri State (289) | Final | L | -18 |
| 18 | 2019-01-17 | Southeast Missouri State (299) | 69 | 73 | Morehead State (273) | Final | L | -4 |
| 19 | 2019-01-19 | Southeast Missouri State (299) | 83 | 85 | Eastern Kentucky (222) | Final | L | -2 |
| 20 | 2019-01-24 | SIU-Edwardsville (328) | 87 | 86 | Southeast Missouri State (315) | Final/3OT | L | -1 |
| 21 | 2019-01-26 | Eastern Illinois (210) | 59 | 64 | Southeast Missouri State (315) | Final | W | 5 |
| 22 | 2019-01-31 | Southeast Missouri State (314) | 71 | 97 | Belmont (59) | Final | L | -26 |
| 23 | 2019-02-02 | Southeast Missouri State (314) | 50 | 79 | Tennessee State (324) | Final | L | -29 |
| 24 | 2019-02-07 | Tennessee Tech (320) | 66 | 71 | Southeast Missouri State (324) | Final/OT | W | 5 |
| 25 | 2019-02-09 | Jacksonville State (140) | 81 | 64 | Southeast Missouri State (324) | Final | L | -17 |
| 26 | 2019-02-14 | Southeast Missouri State (321) | 72 | 81 | Tennessee-Martin (306) | Final | L | -9 |
| 27 | 2019-02-16 | Southeast Missouri State (321) | 88 | 79 | Eastern Illinois (230) | Final | W | 9 |
| 28 | 2019-02-21 | Southeast Missouri State (315) | 70 | 83 | Austin Peay (121) | Final | L | -13 |
| 29 | 2019-02-23 | Southeast Missouri State (315) | 67 | 103 | Murray State (62) | Final | L | -36 |
| 30 | 2019-02-28 | Tennessee State (304) | 74 | 89 | Southeast Missouri State (317) | Final | W | 15 |
| 31 | 2019-03-02 | Belmont (50) | 84 | 66 | Southeast Missouri State (317) | Final | L | -18 |