Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-04 | Evansville (239) | 51 | 82 | Purdue (17) | Final | W | 31 |
| 2 | 2025-11-07 | Oakland (189) | 77 | 87 | Purdue (17) | Final | W | 10 |
| 3 | 2025-11-13 | Purdue (17) | 87 | 80 | Alabama (6) | Final | W | 7 |
| 4 | 2025-11-16 | Akron (80) | 79 | 97 | Purdue (17) | Final | W | 18 |
| 5 | 2025-11-20 | Memphis (29) | 71 | 80 | Purdue (17) | Final | W | 9 |
| 6 | 2025-11-21 | Texas Tech (10) | 56 | 86 | Purdue (17) | Final | W | 30 |
| 7 | 2025-11-28 | Eastern Illinois (317) | 62 | 109 | Purdue (17) | Final | W | 47 |
| 8 | 2025-12-02 | Purdue (3) | 81 | 65 | Rutgers (146) | Final | W | 16 |
| 9 | 2025-12-06 | Iowa State (12) | 81 | 58 | Purdue (3) | Final | L | -23 |
| 10 | 2025-12-10 | Minnesota (153) | 57 | 85 | Purdue (9) | Final | W | 28 |
| 11 | 2025-12-13 | Marquette (176) | 59 | 79 | Purdue (9) | Final | W | 20 |
| 12 | 2025-12-20 | Auburn (31) | 60 | 88 | Purdue (10) | Final | W | 28 |
| 13 | 2025-12-29 | Kent State (70) | 60 | 101 | Purdue (9) | Final | W | 41 |
| 14 | 2026-01-03 | Purdue (9) | 89 | 73 | Wisconsin (75) | Final | W | 16 |
| 15 | 2026-01-07 | Washington (75) | 73 | 81 | Purdue (7) | Final | W | 8 |
| 16 | 2026-01-10 | Penn State (122) | 85 | 93 | Purdue (7) | Final | W | 8 |
| 17 | 2026-01-14 | Iowa (36) | 72 | 79 | Purdue (7) | Final | W | 7 |
| 18 | 2026-01-17 | Purdue (7) | 69 | 64 | USC (37) | Final | W | 5 |
| 19 | 2026-01-20 | Purdue (6) | 67 | 69 | UCLA (55) | Final | L | -2 |
| 20 | 2026-01-24 | Illinois (12) | 88 | 82 | Purdue (6) | Final | L | -6 |
| 21 | 2026-01-27 | Purdue (10) | 67 | 72 | Indiana (46) | Final | L | -5 |
| 22 | 2026-02-01 | Purdue (11) | 93 | 63 | Maryland (143) | Final | W | 30 |
| 23 | 2026-02-07 | Oregon (104) | 64 | 68 | Purdue (11) | Final | W | 4 |
| 24 | 2026-02-10 | Purdue (11) | 80 | 77 | Nebraska (7) | Final/OT | W | 3 |
| 25 | 2026-02-14 | Purdue (11) | 78 | 57 | Iowa (26) | Final | W | 21 |
| 26 | 2026-02-17 | Michigan (1) | 91 | 80 | Purdue (9) | Final | L | -11 |
| 27 | 2026-02-20 | Indiana (37) | 64 | 93 | Purdue (9) | Final | W | 29 |
| 28 | 2026-02-26 | Michigan State (10) | 76 | 74 | Purdue (8) | Final | L | -2 |
| 29 | 2026-03-01 | Purdue (13) | 74 | 82 | Ohio State (37) | Final | L | -8 |
| 30 | 2026-03-04 | Purdue (13) | 70 | 66 | Northwestern (85) | Final | W | 4 |
| 31 | 2026-03-07 | Wisconsin (31) | 97 | 93 | Purdue (13) | Final | L | -4 |
| 32 | 2026-03-12 | Northwestern (83) | 68 | 81 | Purdue (13) | Final | W | 13 |
| 33 | 2026-03-13 | Purdue (13) | 74 | 58 | Nebraska (11) | Final | W | 16 |
| 34 | 2026-03-14 | Purdue (13) | 73 | 66 | UCLA (32) | Final | W | 7 |
| 35 | 2026-03-15 | Purdue (11) | 80 | 72 | Michigan (1) | Final | W | 8 |
| 36 | 2026-03-20 | Queens (158) | 71 | 104 | Purdue (11) | Final | W | 33 |
| 37 | 2026-03-22 | Miami (26) | 69 | 79 | Purdue (11) | Final | W | 10 |
| 38 | 2026-03-26 | Texas (47) | 77 | 79 | Purdue (11) | Final | W | 2 |
| 39 | 2026-03-28 | Purdue (11) | 64 | 79 | Arizona (3) | Final | L | -15 |