Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-11-08 | Nicholls State (177) | 72 | 85 | Louisville (35) | Final | W | 13 |
| 2 | 2018-11-13 | Southern (336) | 54 | 104 | Louisville (119) | Final | W | 50 |
| 3 | 2018-11-16 | Vermont (67) | 78 | 86 | Louisville (119) | Final | W | 8 |
| 4 | 2018-11-21 | Louisville (45) | 81 | 92 | Tennessee (38) | Final | L | -11 |
| 5 | 2018-11-23 | Louisville (45) | 74 | 77 | Marquette (59) | Final/OT | L | -3 |
| 6 | 2018-11-27 | Michigan State (14) | 78 | 82 | Louisville (111) | Final/OT | W | 4 |
| 7 | 2018-12-01 | Louisville (111) | 70 | 65 | Seton Hall (70) | Final | W | 5 |
| 8 | 2018-12-05 | Central Arkansas (242) | 41 | 86 | Louisville (41) | Final | W | 45 |
| 9 | 2018-12-08 | Louisville (41) | 67 | 68 | Indiana (33) | Final | L | -1 |
| 10 | 2018-12-12 | Lipscomb (61) | 68 | 72 | Louisville (28) | Final | W | 4 |
| 11 | 2018-12-15 | Kent State (74) | 70 | 83 | Louisville (28) | Final | W | 13 |
| 12 | 2018-12-21 | Robert Morris (306) | 59 | 73 | Louisville (24) | Final | W | 14 |
| 13 | 2018-12-29 | Kentucky (30) | 71 | 58 | Louisville (26) | Final | L | -13 |
| 14 | 2019-01-06 | Miami (90) | 73 | 90 | Louisville (27) | Final | W | 17 |
| 15 | 2019-01-09 | Louisville (28) | 86 | 89 | Pittsburgh (81) | Final/OT | L | -3 |
| 16 | 2019-01-12 | Louisville (28) | 83 | 62 | North Carolina (15) | Final | W | 21 |
| 17 | 2019-01-16 | Boston College (113) | 70 | 80 | Louisville (24) | Final | W | 10 |
| 18 | 2019-01-19 | Louisville (24) | 79 | 51 | Georgia Tech (79) | Final | W | 28 |
| 19 | 2019-01-24 | North Carolina State (32) | 77 | 84 | Louisville (19) | Final | W | 7 |
| 20 | 2019-01-26 | Pittsburgh (58) | 51 | 66 | Louisville (19) | Final | W | 15 |
| 21 | 2019-01-30 | Louisville (14) | 82 | 54 | Wake Forest (160) | Final | W | 28 |
| 22 | 2019-02-02 | North Carolina (10) | 79 | 69 | Louisville (14) | Final | L | -10 |
| 23 | 2019-02-04 | Louisville (14) | 72 | 64 | Virginia Tech (13) | Final | W | 8 |
| 24 | 2019-02-09 | Louisville (16) | 75 | 80 | Florida State (24) | Final/OT | L | -5 |
| 25 | 2019-02-12 | Duke (1) | 71 | 69 | Louisville (17) | Final | L | -2 |
| 26 | 2019-02-16 | Clemson (38) | 55 | 56 | Louisville (17) | Final | W | 1 |
| 27 | 2019-02-20 | Louisville (18) | 49 | 69 | Syracuse (41) | Final | L | -20 |
| 28 | 2019-02-23 | Virginia (2) | 64 | 52 | Louisville (18) | Final | L | -12 |
| 29 | 2019-02-27 | Louisville (25) | 59 | 66 | Boston College (107) | Final | L | -7 |
| 30 | 2019-03-03 | Notre Dame (92) | 61 | 75 | Louisville (25) | Final | W | 14 |
| 31 | 2019-03-09 | Louisville (28) | 68 | 73 | Virginia (1) | Final | L | -5 |
| 32 | 2019-03-13 | Notre Dame (107) | 53 | 75 | Louisville (26) | Final | W | 22 |
| 33 | 2019-03-14 | Louisville (26) | 70 | 83 | North Carolina (4) | Final | L | -13 |
| 34 | 2019-03-21 | Minnesota (38) | 86 | 76 | Louisville (28) | Final | L | -10 |