Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-11-06 | Alabama State (343) | 53 | 79 | Iowa State (92) | Final | W | 26 |
| 2 | 2018-11-09 | Missouri (42) | 59 | 76 | Iowa State (92) | Final | W | 17 |
| 3 | 2018-11-12 | Texas Southern (277) | 73 | 85 | Iowa State (92) | Final | W | 12 |
| 4 | 2018-11-19 | Arizona (13) | 71 | 66 | Iowa State (17) | Final | L | -5 |
| 5 | 2018-11-20 | Iowa State (29) | 84 | 68 | Illinois (124) | Final | W | 16 |
| 6 | 2018-11-21 | San Diego State (80) | 57 | 87 | Iowa State (29) | Final | W | 30 |
| 7 | 2018-11-26 | Nebraska-Omaha (301) | 55 | 82 | Iowa State (29) | Final | W | 27 |
| 8 | 2018-12-03 | North Dakota State (237) | 59 | 81 | Iowa State (39) | Final | W | 22 |
| 9 | 2018-12-06 | Iowa State (20) | 84 | 98 | Iowa (14) | Final | L | -14 |
| 10 | 2018-12-09 | Southern (343) | 65 | 101 | Iowa State (20) | Final | W | 36 |
| 11 | 2018-12-15 | Iowa State (38) | 77 | 68 | Drake (91) | Final | W | 9 |
| 12 | 2018-12-21 | Eastern Illinois (209) | 53 | 101 | Iowa State (34) | Final | W | 48 |
| 13 | 2019-01-02 | Iowa State (30) | 69 | 63 | Oklahoma State (106) | Final | W | 6 |
| 14 | 2019-01-05 | Kansas (3) | 60 | 77 | Iowa State (30) | Final | W | 17 |
| 15 | 2019-01-08 | Iowa State (20) | 70 | 73 | Baylor (115) | Final | L | -3 |
| 16 | 2019-01-12 | Kansas State (49) | 58 | 57 | Iowa State (20) | Final | L | -1 |
| 17 | 2019-01-16 | Iowa State (37) | 68 | 64 | Texas Tech (6) | Final | W | 4 |
| 18 | 2019-01-19 | Oklahoma State (80) | 59 | 72 | Iowa State (37) | Final | W | 13 |
| 19 | 2019-01-21 | Iowa State (37) | 76 | 80 | Kansas (7) | Final | L | -4 |
| 20 | 2019-01-26 | Iowa State (21) | 87 | 73 | Ole Miss (28) | Final | W | 14 |
| 21 | 2019-01-30 | West Virginia (107) | 68 | 93 | Iowa State (21) | Final | W | 25 |
| 22 | 2019-02-02 | Texas (43) | 60 | 65 | Iowa State (21) | Final | W | 5 |
| 23 | 2019-02-04 | Iowa State (21) | 75 | 74 | Oklahoma (19) | Final | W | 1 |
| 24 | 2019-02-09 | TCU (32) | 92 | 83 | Iowa State (18) | Final | L | -9 |
| 25 | 2019-02-16 | Iowa State (22) | 78 | 64 | Kansas State (24) | Final | W | 14 |
| 26 | 2019-02-19 | Baylor (42) | 73 | 69 | Iowa State (17) | Final | L | -4 |
| 27 | 2019-02-23 | Iowa State (17) | 72 | 75 | TCU (31) | Final | L | -3 |
| 28 | 2019-02-25 | Oklahoma (35) | 61 | 78 | Iowa State (17) | Final | W | 17 |
| 29 | 2019-03-02 | Iowa State (27) | 69 | 86 | Texas (42) | Final | L | -17 |
| 30 | 2019-03-06 | Iowa State (27) | 75 | 90 | West Virginia (115) | Final | L | -15 |
| 31 | 2019-03-09 | Texas Tech (10) | 80 | 73 | Iowa State (27) | Final | L | -7 |
| 32 | 2019-03-14 | Iowa State (29) | 83 | 66 | Baylor (44) | Final | W | 17 |
| 33 | 2019-03-15 | Iowa State (29) | 63 | 59 | Kansas State (19) | Final | W | 4 |
| 34 | 2019-03-16 | Iowa State (29) | 78 | 66 | Kansas (12) | Final | W | 12 |
| 35 | 2019-03-22 | Ohio State (41) | 62 | 59 | Iowa State (24) | Final | L | -3 |