Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-11-10 | Alabama A&M (351) | 54 | 101 | Houston (15) | Final | W | 47 |
| 2 | 2018-11-14 | Rice (265) | 68 | 79 | Houston (82) | Final | W | 11 |
| 3 | 2018-11-19 | Northwestern State (268) | 55 | 82 | Houston (82) | Final | W | 27 |
| 4 | 2018-11-24 | Houston (65) | 76 | 62 | BYU (88) | Final | W | 14 |
| 5 | 2018-11-28 | UTRGV (199) | 53 | 58 | Houston (40) | Final | W | 5 |
| 6 | 2018-12-01 | Oregon (41) | 61 | 65 | Houston (40) | Final | W | 4 |
| 7 | 2018-12-04 | Lamar (249) | 56 | 79 | Houston (32) | Final | W | 23 |
| 8 | 2018-12-08 | Houston (32) | 63 | 53 | Oklahoma State (108) | Final | W | 10 |
| 9 | 2018-12-12 | LSU (47) | 76 | 82 | Houston (18) | Final | W | 6 |
| 10 | 2018-12-16 | Saint Louis (60) | 64 | 68 | Houston (18) | Final | W | 4 |
| 11 | 2018-12-20 | Utah State (38) | 50 | 60 | Houston (10) | Final | W | 10 |
| 12 | 2018-12-23 | Coppin State (353) | 44 | 75 | Houston (10) | Final | W | 31 |
| 13 | 2018-12-29 | NJIT (108) | 59 | 80 | Houston (7) | Final | W | 21 |
| 14 | 2019-01-02 | Tulsa (77) | 56 | 74 | Houston (6) | Final | W | 18 |
| 15 | 2019-01-06 | Memphis (99) | 77 | 90 | Houston (6) | Final | W | 13 |
| 16 | 2019-01-09 | Houston (4) | 69 | 73 | Temple (50) | Final | L | -4 |
| 17 | 2019-01-12 | Wichita State (128) | 70 | 79 | Houston (4) | Final | W | 9 |
| 18 | 2019-01-16 | Houston (9) | 69 | 58 | SMU (104) | Final | W | 11 |
| 19 | 2019-01-19 | Houston (9) | 69 | 60 | South Florida (90) | Final | W | 9 |
| 20 | 2019-01-23 | East Carolina (199) | 50 | 94 | Houston (8) | Final | W | 44 |
| 21 | 2019-01-27 | Houston (8) | 77 | 65 | Tulsa (88) | Final | W | 12 |
| 22 | 2019-01-31 | Temple (40) | 66 | 73 | Houston (7) | Final | W | 7 |
| 23 | 2019-02-07 | Houston (6) | 77 | 68 | Central Florida (41) | Final | W | 9 |
| 24 | 2019-02-10 | Cincinnati (22) | 58 | 65 | Houston (6) | Final | W | 7 |
| 25 | 2019-02-14 | Houston (6) | 71 | 63 | Connecticut (92) | Final | W | 8 |
| 26 | 2019-02-17 | Houston (6) | 85 | 50 | Tulane (297) | Final | W | 35 |
| 27 | 2019-02-23 | South Florida (78) | 59 | 71 | Houston (5) | Final | W | 12 |
| 28 | 2019-02-27 | Houston (4) | 99 | 65 | East Carolina (224) | Final | W | 34 |
| 29 | 2019-03-02 | Central Florida (34) | 69 | 64 | Houston (4) | Final | L | -5 |
| 30 | 2019-03-07 | SMU (132) | 79 | 90 | Houston (8) | Final | W | 11 |
| 31 | 2019-03-10 | Houston (8) | 85 | 69 | Cincinnati (16) | Final | W | 16 |
| 32 | 2019-03-15 | Connecticut (105) | 45 | 84 | Houston (7) | Final | W | 39 |
| 33 | 2019-03-16 | Memphis (59) | 58 | 61 | Houston (7) | Final | W | 3 |
| 34 | 2019-03-17 | Cincinnati (22) | 69 | 57 | Houston (7) | Final | L | -12 |
| 35 | 2019-03-22 | Georgia State (91) | 55 | 84 | Houston (8) | Final | W | 29 |
| 36 | 2019-03-24 | Ohio State (41) | 59 | 74 | Houston (8) | Final | W | 15 |
| 37 | 2019-03-29 | Houston (8) | 58 | 62 | Kentucky (7) | Final | L | -4 |